BIOSC 150 1nd Edition Lecture 10 Outline of Last Lecture I Subcellular Structures Outline of Current Lecture 1 Subcellular structures continued A Intermediate filaments and microtubules 2 Disease Current Lecture Three types of filamentous proteins comprising the cytoskeleton 1 Microfilaments actin small diameter polymer made of actin monomers 2 Intermediate Filaments intermediate diameter polymer made of various proteins depending on the cell type 3 Microtubules large diameter polymer made of the proteins alpha and beta tubulin Use crystallography to see three dimensional structure of a protein Use scanning electron microscopy to look at the surface of tissue and large objects Intermediate filaments provide the cell with tensile strength 1 2 3 4 5 Long chains more elongated than actin Huge diverse array Rope like structure Good to resist tense forces Can distinguish different cell types IF cell type can help to show the origin of the cell type therefore determining a treatment plan for cancer in particular Metastatic cancer Demosomes intermediate filaments that are critical for cell cell interactions Hemidesomes intermediate filaments critical for cell substratum interactions Intermediate filaments help to structure the cell These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Nuclear lamins are IFs that give the nucleus shape and anchor chromosomes IF subunits are anti parallel heterotetramers four different subunits IFs have no directionality because both ends are identical Microtubules are composed of alpha and beta tubulin heterodimers Microtubules form a radical network in the cell Microtubules organize at the microtubule organizing center MTOC MTOC in animal cells is the centrosome Microtubules are asymmetric and have polarity Microtubules are important for directional transport of cargo within cells Motors walk along microtubules using energy in the form of ATP Kinesin and dynein control coloration in fish
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