BIOSC 150 1nd Edition Lecture 5 Outline of Last Lecture I Ptroteins Outline of Current Lecture II Hemoglobin A Hemoglobin factor in disease III Patient Study Cases IV Sickle Cell Disease Current Lecture When identifying sickle cell disease send out blood samples to be viewed under a microscope Red blood cells are packed with hemoglobin to carry oxygen Sickle cells block blood flow leading to pain and swelling a Sickle cells are sticky and stif b The stifness and stickiness leads to the blockage Oxygen concentration is high in the lungs and low in peripheral tissues Sickle red blood cells are filled with fibers Normal blood cells are not filled with fibers Red blood cells sickle on slide when oxygen concentration is lowered One may perform a test to determine which biomolecule makes up the sickle cell a The cell could be composed of lipids carbs proteins or nucleic acid b A possible test would include using specific dyes to identify the biomolecule c Another test would include adding particular reagents to the cell The fibers are composed of abnormal hemoglobin protein This discovery was found by using an electrical field to separate the proteins and peptides These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute The normal cell peptide contains the amino side chain Glu at the 6 th position The sickle cell peptide contains the amino side chain Val at the 6 th position This small change in one amino group cause the whole cell to function and react diferently Sickle disease is hereditary because DNA codes for the proteins
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