Chapter 17: Transplantation Immunology Abbas, Lichtman and Pillai8_Figure 17-1; p.360 Abbas, Lichtman and Pillai8_Figure 17-2; p.361Types of grafts: Autologous graft – Syngeneic graft – Allogeneic graft (allograft) – Xenogeneic graft (xenograft) – Abbas, Lichtman and Pillai8_Figure 17-3; p.362Direct and Indirect Allorecognition Direct allorecognition – Indirect allorecognition – Direct allorecognition Abbas, Lichtman and Pillai8_Figure 17-4; p.363 Abbas, Lichtman and Pillai8_Figure 17-5; p.364Overall result of allorecognition: Alloreactive Lymphocyte Activation Note: This may be a good time to review what happens when TCRs are engaged with their respective ligand and the molecules present during T cell activation. Abbas, Lichtman and Pillai8_Figure 17-6; p.366 Abbas, Lichtman and Pillai8_Figure 17-5; p.364Sensitization – Mixed Lymphocyte Reaction (MLR) How the MLR is performed: 1 – 2 – 3 – Abbas, Lichtman and Pillai8_Figure 17-7; p.367Types of Graft Rejection Hyperacute rejection Acute rejection Abbas, Lichtman and Pillai8_Figure 17-8A; p.369 Abbas, Lichtman and Pillai8_Figure 17-8B; p.369Chronic rejection How can we prevent transplant rejection? Abbas, Lichtman and Pillai8_Figure 17-8C; p.369A key to successful transplant – T cells Abbas, Lichtman and Pillai8_Figure 17-10; p.372 Abbas, Lichtman and Pillai8_Figure 17-11; p.373Blood Transfusions – A specialized type of tissue transplant Please note, this is not the same as a bone marrow transplant or a stem cell transplant. ABO antigens Abbas, Lichtman and Pillai8_Figure 17-13A; p.378 Abbas, Lichtman and Pillai8_Figure 17-13B; p.378Rh antigen Stem Cell Transplant Graft-Versus-Host-Disease (GVHD)
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