Chapter 13 Learning Objectives Define the following terms:Neutralization Opsonization Major basic protein Isotype Neonatal Immunity Transcytosis Mucosal immunity Feedback inhibition Thioester group Covalent bond Hydrolysis C1 INH Serine protease SERPIN DAF CR1 Factor D Factor H Factor I MCP CD59 S protein Cell-mediated immunity Humoral immunity Anaphylatoxin Fluid phaseAntibody-dependent cellular cytotoxicity (ADCC) Learning Objectives - Important concepts to know At the end of this chapter, you should be able to: 1. Describe the various functions antibodies can perform. What cells do they interact with in each of these situations and what is the result of this interaction? 2. In detail and using examples, describe the various effector functions of each of the antibody isotypes discussed. 3. Compare neonatal immunity and mucosal immunity. What antibody isotype is involved in each of these types of immunity and how do they provide protection to the host? 4. Using examples, explain how neutralization protects the host. Integrate the importance of this antibody isotype, the location within the body, and the effector function of the antibody. 5. Describe the process of phagocytosis and the role of opsonization in protecting the host. 6. Explain the process of antibody-dependent cell mediated cytotoxicity, (ADCC) including: a. The cells that can perform this function b. The antibody isotype required c. The consequence of ADCC7. Discuss how our body protects us from parasites and helminths, including the antibody isotype(s), immune cell involved, and antibody receptors required for this function. 8. Compare the beginning stages of the alternative complement pathway and the classical complement pathway. What initial events are required to stimulate their respective complement cascades? 9. Describe the difference between the inactive and active forms of C3b. What is the fluid phase of C3b? 10. Explain when IgM and IgG can, and cannot, stimulate the classical complement pathway. 11. Using examples, discuss the various mechanisms that can be employed to inhibit the complement cascade. In your answer, please include the name of the inhibitory molecule(s) involved and their effect on the complement cascade. Why is inhibiting the complement pathway necessary? **Please remember to review the 3 different complement pathways: how are each of the pathways initiated, what components do they have in common with one another, which components are different, what type of infection(s) are each of the pathways beneficial for eliminating from the body?** Please look up the following information in your textbook: Please read the section on Complement Deficiencies (p. 285-286) in your text and identify the specific complement deficiencies associated with the following diseases: Systemic lupus erythematosus (SLE) – Neisseria species – Leukocyte adhesion deficiency (LAD) – Please read the section on “Evasion of Complement by Microbes” on p.
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