Chapter 7: Immune Receptors and Signal Transduction The function of cell surface receptors: Abbas, Lichtman and Pillai8_Figure 7-1; p.138Signal Receptor Categories: Non-receptor tyrosine kinase – Receptor tyrosine kinase – Nuclear receptors – GPCRs – Notch – Abbas, Lichtman and Pillai8_Figure 7-2; p.139Immune receptors: some key players… The T Cell Receptor (TCR) and the TRC Complex: Abbas, Lichtman and Pillai8_Figure 7-5; p.142 Abbas, Lichtman and Pillai8_Figure 7-8; p.145**Note the activating and inhibitory molecules. Also note that CD4 and CD8 bind directly to MHC. Interestingly, CD4 is the coreceptor HIV uses to gain access to these helper T cells. Abbas, Lichtman and Pillai8_Figure 7-9; p.146**Please do not memorize the figure above. It is only included for completion and to connect the idea of how signals are transduced into cell upon receptor ligand interaction (from Figure 7-9A).** Abbas, Lichtman and Pillai8_Figure 7-11; p.148The Immunologic Synapse The Ras-MAPK Pathway Abbas, Lichtman and Pillai8_Figure 7-13B; p.150 Abbas, Lichtman and Pillai8_Figure 7-14; p.151Activated T Cell Transcription Factors Abbas, Lichtman and Pillai8_Figure 7-16; p.154B cell signaling involves cross-linking Complement and B cell activation Abbas, Lichtman and Pillai8_Figure 7-19; p.158 Abbas, Lichtman and Pillai8_Figure 7-20;
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