Name Printed Signature Version 1 Exam 3 April 1 2013 BSC 2010 Introductory Biology Part I Knowing the Vocabulary For questions 1 14 identify which word if any fits the given definition as defined by the textbook and vocabulary lists 1 A short stretch of RNA with a free 3 end bound by complementary base pairing to the template strand and elongated with DNA nucleotides during DNA replication a okazaki fragment b primer c DNA ligase d siRNA e none of the above 2 The tandemly repetitive DNA at the end of a eukaryotic chromosome s DNA molecule a telomere b promoter c bacteriophage d nuclease e none of the above 3 a nucleogenesis b transcription c translation d replication e none of the above Eukaryotic chromatin that remains highly compacted during interphase and is generally not transcribed a chromosome b euchromatin c apochromatin d heterochromatin e none of the above 4 The synthesis of a polypeptide using the genetic information encoded in an mRNA molecule 5 A specific nucleotide sequence in the DNA of a gene that binds RNA polymerase positioning it to start transcribing RNA at the appropriate place a inducer b enhancer c promoter d activator e none of the above 6 A chemical or physical agent that interacts with DNA and can cause a mutation a initiator b inhibitor c oncogene d exon e none of the above 7 A specific small molecule that binds to a bacterial repressor protein and changes the repressor s shape so that it cannot bind to an operator thus switching an operon on a repressor b activator c deactivator d enhancer e none of the above 8 The process by which a cell or group of cells become specialized in structure and function 9 A gene found in viral or cellular genomes that is involved in triggering molecular events that 10 A general outbreak of a disease a evolution b transformation c metamorphosis d morphometrics e none of the above can lead to cancer a oncogene b operon c intron d mutagen e none of the above a differentiation b pandemic c endemic d epidemic e none of the above a prion b viroid c virus d phage e none of the above 11 An infectious agent that is a misfolded version of a normal cellular protein 12 A technique that enables specific nucleotide sequences to be detected in samples of DNA a western blotting b northern blotting c polymerase chain reaction PCR d genetic recombination e none of the above 13 A small circular double stranded DNA molecule that carries accessory genes separate from those of a bacterial chromosome in DNA cloning used as vectors carrying up to about 10 000 base pairs 10 kb of DNA a plasmid b primer c regulatory gene d cDNA e none of the above 14 Describing a cell that can give rise to many but not all parts of an organism a totipotent b pluripotent c omnipotent d egg e none of the above Part II Understanding the Homework 15 If a sample of double stranded DNA is found to have 20 of its bases composed of adenine which of the following is an accurate conclusion a guanine will make up 70 of the DNA b guanine will make up 40 of the DNA c guanine will make up 30 of the DNA d guanine will make up 20 of the DNA e None of the above is accurate 16 In DNA replication how do the leading and lagging strand differ a The leading strand is synthesized in the same direction as the movement of the replication fork and the lagging strand is synthesized in the opposite direction b The leading strand is synthesized at twice the rate of the lagging strand c The leading strand is synthesized in short fragments that are ultimately stitched together whereas the lagging strand is synthesized continuously d The leading strand is synthesized by adding nucleotides to the 3 end of the growing strand and the lagging strand is synthesized by adding nucleotides to the 5 end e The leading strand is synthesized first and the lagging strand second 17 Which of the following is true of heterochromatin but not of euchromatin a It is accessible to enzymes needed for gene expression b It becomes less tightly compacted after cell division c It includes DNA primarily found in expressed genes d It remains tightly coiled or condensed during interphase e It contains the genes that determine an organisms sex 18 The flow of genetic information in a cell proceeds in what sequence a from RNA to protein to DNA b from RNA to DNA to protein c from protein to RNA to DNA d from DNA to protein to RNA e from DNA to RNA to protein 19 Using the genetic code above which of the following protein sequences would be coded for by the RNA sequence AGA GGU GAC a Gly Ser Glu b Gly Ser Asp c Arg Gly Asp d Arg Ser Glu e No protein sequence would be produced as the first codon is a stop codon 20 Which of the following types of mutation resulting in an error in the mRNA just after the AUG start of translation is likely to have the most serious effect on the polypeptide product a a deletion of two nucleotides b a substitution of the first nucleotide of a GGG codon c an insertion of a codon d a deletion of a codon e a substitution of the third nucleotide in an ACC codon 21 Which of the following is not an event that happens in translation a the polypeptide chane elongates by formation of a peptide bond b an aminoacyl tRNA molecule binds to the mRNA by means of an anticodon c the mRNA is translocated along the ribosome d a ribonucluetide is added to the 3 end of the mRNA e translation stops when the stop codon is reached 22 Suppose an experimenter becomes proficient with a technique that allows her to move DNA sequences within a prokaryotic genome If she moves the repressor gene lac I along with its promoter to a position at some several thousand base pairs away from its normal position which will you expect to occur a The lac operon will be expressed continuously b The repressor will no longer bind to the inducer c The lac operon will function normally d The repressor will no longer be made e The repressor will no longer bind to the operator 23 Which of the following statements best describes the lytic cycle of the lambda phage a The viral genes turn the host cell into a lambda producing factory and the host cell then lyses cell s DNA b The phage DNA is incorporated by crossing over into any nonspecific site on the host c The phage genome replicates along with the host genome d Most of the prophage genes are activated by the product of a particular prophage gene e Certain environmental triggers can cause the phage to exit the host genome switching from the lytic to the lysogenic 24 Which enzyme do retroviruses
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