MIC 205 1st Edition Lecture 27Outline of Last LectureI. Nervous System Diseases cont.a. Protozoanb. PrionII. Cardiovascular system diseases Outline of Current Lecture III. Cardiovascular System Diseases Cont.IV. Respiratory System Diseases Cont.Current Lecture 20 ? on cumulative final exam (broad overarching topics) –review previous topics and 3-4 chunks of information (chapters/learning modules)45 ?’s on unit 4 exam (19, 20, 21, 22, 23) not much on 22/23Plague (Black Death)- Caused by gram negative coccobacillus Yersinia pestis - Transmitted by rat flea- Xenopsylla cheopis (vector) to rodents (resevoirs) to humans (amplifying hosts)- Swollen lymph nodes, become buboes and then become nectrotic- Disseminated intravascular coagulation (pathological activation of blood clotting that causes bleeding from skinInfectious Mononucleosis (Mono)- Caused by Epstein Barr virus (EBV)- Signs/Symp: splenomegaly and extreme fatigue - Life long infection results when EBV goes (latent) - Transmission from saliva - EBV infects B lymphocytes and turns them immortal (possible cancer causing)o Humoral immune response o Keeps T cells from being able to find them - The effect of EBV depends on strength of cellular immunity (t cell immunity) These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.Diseases of Respiratory System:- Streptococcal Respiratory Diseases (Streptococcal pharyngitis-Strep throat)o Caused by Streptococci Pyogenes o Sore throat May progress to scarlet fever or rheumatic fevero Treatment: Beta Lactams- Scarlet Fevero Sandpaper rash that starts on chest and then spreads (NO vesicles) Goes away in a week - Rheumatic Fever and Heart Diseaseo Secondary inflammatory disease Joint pain, damage connective tissues to heart (rheumatic heart disease) Damage to heart is permanent - Diphtheria o Caused by Cornybacterium diptheriae Diphtheria toxin - Prevents polypeptide synthesis and causes cell death Signs: sore throat, pseudomembrane that obstructs airway- Common Coldo Caused by Rhinoviruses and Coronaviruses- Bacterial Pneumonias o Inflammation of lungs o Caused by bacteria, viruses and fungi Lobar- entire lobes of lungs Mycoplasmal- caused by Mycobacterium sp. Nosocomial- caused in health care settingso Primary Causative Agents of Bacterial Pneumonias: Streptococcus pneumonia Mycoplasma pneumonia Klebsiella pneumonia- Severe Acute Respiratory Syndrome (SARS)o Caused by SARS-associated coronavirus Causes many common colds Death rate was HUGEo More severe symptoms than
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