- MIC 205 1st Edition Lecture 22Outline of Last LectureI. 3rd line of defense-Immunity Outline of Current Lecture II. Microbial Diseasesa. Skin Current Lecture Normal Microbiota of the Skin-- Skin microbiota normally harmless (GRAM POSITIVE)o Bacteria- Gram positive coci aerobic (Staphylococcus and Micrococcus) Gram positive rods, anaerobes (Diphtheroids)o Yeast: Malassezia- Can never be fully removed from the skin (can be opportunistic pathogens)Bacteria Diseases of Skin- EX:o Folliculitis: Pimple- infected pore in skin, red bump (sty- near eye) Treatment: methicillin- Caused by S. aureus typically (which also causes a ton of other illnesses) S. aureus has a lot of virulence factorso Staph- grape like bundleso Strep- chainso Staphylococcal scalded skin syndrome (SSS) Caused by S. aureus- Exfoliative toxins Signs/Symptoms:- Outer layers of skin peel off body in sheets (often in babies)- No scarring Treatment: antimicrobial drugsThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.o Impetigo and erysipelas Caused by Staph aureus and Strep pyogenes- Impetigo(Pyoderma): small red patches on face and limbs, pus-filled vesicles (Children)- Erysipelas: goes internal, lymphatic system (elderly individuals) Transmitted person to person Treated: penicillino MRSA infections Methicillin-resistant S. aureus- Signs/Sypmtoms: may start as folliculi (pimple) develops into deep abscesso Penetrate tissue, bone, organs- Strain of S. aureus that are drug resistant - Found in hospitals (HA-MRSA)- Community associated (CA-MRSA)- Treatment:o Drain and debriding the dead stuff Along with vancomycin - SUPER MRSA- vancomycin resistant o Necrotizing Fasciitis Red inflamed area on skin, blistering turns black- INTENSE PAIN o From Streptococcus pyogenes - Treatment: removal of infected tissues, antimicrobial drugso Acne Caused by P. acnes - Gram positive, rod, grow in sebaceous glands- Normal microbe Treatment:- Retinoic acid (prevent oil production)- Blue light exposure to destroy the
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