MIC 205 1st Edition Lecture 21Outline of Last LectureI. Nonspecific defensesa. Second line i. Phagocytosisii. Inflammationiii. Feveriv. Nonspecific chemical defenses Outline of Current Lecture II. 3rd line of defense-ImmunityIII.Current Lecture 3rd Line of Defense:- Specific Immunityo Body’s ability to recognize and defend itself against DISTINCT INVADERS Outline: (Antigens, lymphatic system, B cells and antibodies, humoral immune response, cell-mediated immune response)o Acquired over time as body is exposed to the environment Antigens = any molecule that can elicit a specific immune response- EX) Bacterial cell walls, capsules, pili, flagella, viral proteins, fungio Epitope: region of a molecule that has antigenic properties Lymphatic system = screens the tissues for foreign antigens- EX) Lymph nodes, lymphatic vessels, spleen, tonsilso Lymph: fluid collectedo Lymphoid cells: lymphocytes (smallest of white blood cells) Type B Lymphocytes (B cells) = housed in lymph nodes, make antibodies- Antibodies: immunoglobulins, binds to antigens- Humoral Immune response: from antigens in fluid (humor) T cells These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.o Lymphatic vessels: one way system that collects lymph and takes it to the circulatory systemo Lymph nodes: recognize and attack foreign antigens in lymph (neck, groin, armpit)o Spleen: filters bacteria, viruses, toxins from bloodo Tonsils: trap particles Antibody Structure: 4 poly peptides, covalent bonds- Heavy chains and light chains- 2 antigen binding sites/antibody molecule (bind same antigen) Antibody Classes: - IgG and IgM (most common) Antibody Function:- Strong noncovalent interactions with antigens- 5 functions of binding:o Activation of complemento Stimulation of inflammationo Agglutinationo Neutralizationo Opsonization (activate phagocyte)Humoral Immune Response:o Antibody mediated responses (B CELL)o Plasma B cells- short lived o Memory B cells- long lived Cell Mediated Immune Response:o Responds to intracellular pathogens and abnormal body cells (Cancer)o Targets cellular material, viruses Formation of memory T cells - Type T lymphocytes circulate in lymph and bloodo Look for sick host
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