MIC 205 1st Edition Lecture 16Outline of Last LectureI. Virusesa. Structureb. Categorizingc. ReplicationOutline of Current Lecture II. Virusesa. Role in Cancer III. Infection and Infectious DiseasesCurrent LectureViruses in Cancer- Neoplasia- uncontrolled cell division in multicellular animalo A mass of these cells is a tumor- Benign vs. malignant tumorso Metastasis- sheds cells to migrate throughout the bodyo Cancers - Oncogenes (copies of cell division genes) that are carried as part of the genomePrions- Infectious agent composed of a single protein (PrP)o Neural degenerative diseases- Has 2 forms:o Normal form- alpha helices (“cellular” PrP)o Disease causing form with beta sheets (“prion”PrP)- CAUSATIVE AGENT for human diseases- Only way to sterilize or destroy is: STERILIZATION Symbiotic Relationships- Mutualism- both benefit (ex: bacteria in human colon)- Commensalism- one benefits, one is indifferent (ex: staph on skin)These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.- Parasitism- one benefits, one harmed (ex: tuberculosis bacteria in human lung)Normal Microbiota- Normal flora/ indigenous microbiota- Organisms that colonize the body’s surfaces without normally causing diseaseo Acquired at birth- Two Typeso Resident microbiota Externally oriented features (skin, upper respiratory tract, lower digestive tract, upper digestive tract)- Everything has staph in it except digestive tract- What you are born witho Transient microbiota Remain on body from hours to months Ones experienced in everyday life In same externally oriented areas of the body Cannot stay in the body full time - Not able to grow and divideo Ex: food consumption, kissingOpportunistic Pathogens- Normal microbiota that can cause disease in certain circumstanceso Normal microbiota come into unusual places in the body Ex: resident microbes in wrong place of bodyChain of Infection- Life cycle of a pathogeno Contamination is the presence of microbes on the bodyMucous Membranes- Warm, moist environments that are common to acquire pathogensDisease TransmissionContact- direct/indirectVector- biological entityVehicle- non biological
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