MIC 205 1st Edition Lecture 26Outline of Last LectureI. Nervous System Diseasesa. Viral, bacterial Outline of Current Lecture II. Nervous System Diseases cont.a. ProtozoanCurrent Lecture - Amoebic Meningoencephalopathy (Brain Eating Amoeba)o Caused by Protozoan: Naegleria Found in warm natural/artificial water systems, A/C, contact lens solutiono Portal of entry: cut/scrape on skin, inhale contaminated water, eyelido Signs/Symp: same as memingitiso Typically fatal Makes resistant cysts Swelling in frontal cortex Necrotic tissue- African Sleeping Sickness o Caused by protozoan Trypanosoma bruceio Diagnosed from microscopic observation of trypanosomes in blood, lymph, spinal fluido Transmitted by tsetse flyo Drugs to cure 3 clinical stages:- Bite becomes necrotic lesion- Parasites cause fever and headaches- Crosses meningeal layero Causes meningitis and extreme drowsiness causing coma and deathPrion Diseases - infections proteinso Misfolded protein These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.o Triggered by transplants, contaminated surgical instruments- Variant Creutzfeldt Jakob disease (scrapie, mad cow disease)- VCJ Disease (Variant Creutzfeldt Jakob disease)o Caused by PrP prion proteino Holes in braino Irrational behavior, loss of muscle control and deatho Prevention Do not eat contaminated meatCardiovascular System-Diseases- Structure:o Heart, blood, blood vessels- Portals of infections:o Blood is anxinic (no normal microbes in the system)o Blood and lymph are great distribution systems- Terms of Septicemias o Bacterial infection of blood, blood vessel, tissues of hearto Septicemia = presence of ANY microbial infectious agent in cardiovascular systemo Bacteremia = bacterial septicemia (often harmless)o Toxemia = release of bacterial toxin in bloodo Lymphangitis = infeaction and inflammation of lymphatic vessels- Septicemiaso Signs/Symptoms Fever, chills, nausea- Septic shock develops rapidly (low blood pressure) Petechiae = small hemorrhagic lesions Osteomyeltis occurs when bacteria invades boneo Caused by lots of microbes Direct inoculation of bacteria into bloodo Gram negative causes severe septicemia Endotoxin released as bacteria die (lipid A)o Treatment: Administer antimicrobial drugs- Endocarditis o Bacterial buildup in heart chamberso Caused by Staph, and some Streptococcio Portal of entry: inoculation of bacteria into blood from open woundo Signs/Symp: fever, fatigue, tachycardiao Treatment: IV antibiotics- Malaria o Protozoan caused cardiovascular disease transmitted by mosquito bites 4 Plasmodium species- P. falicarum- P. vivax- P. ovale- P. malariaeo Plasmodium falciparum causes the most severeo Signs and Symp Cyclic symptoms feel better then they reoccur as the parasite replicates in blood streamo Treatment: Drug chloroquine
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