Bio 1B Lecture Outline please print and bring along Fall 2007 B D Mishler Dept of Integrative Biology 2 6810 bmishler berkeley edu Evolution lecture 12 Selection Dec 3rd 2007 464 470 ch 23 in 7th ed 456 461 ch 23 in 6th ed Summary of topics Distinguish between single gene traits and quantitative traits Contrast the short and long term effects of balancing versus directional selection on the genetic structure of a population for Mendelian and quantitative traits Describe examples of heterozygote advantage disruptive selection etc Relate observations on artificial selection to natural selection Contrast Mullerian and Batesian mimicry Understand the concept and describe examples of sexual selection Understand why sex exists Introduction Why are there so few good examples of selection selection has to be very strong to detect it via deviations from HW or direct measurement of differential fitness or fertility On the other hand even relatively weak selection e g 1 can have a major effect on long term evolution Malaria and selection one strong selective pressure which has led to polymorphism of a number of genes in humans is malaria Some examples related to Plasmodium falciparum are 1 Variants at the hemoglobin gene notably Hb S homozygotes have sickle cell anemia also see below and also there is another variant Hb C where homozygotes have a milder anemia in both cases there is heterozygote advantage in malarial environments Both alleles have relatively high frequencies in parts of Africa the Mediterranean the Middle East and India Fig 23 13 7th Fig 23 10 6th 2 Both and thallasemias are found where there is a reduced amount or no production of either the or chains of hemoglobin the hemoglobin molecule is a tetramer of 2 and 2 chains Again there is heterozygote advantage in malarial environments affected individuals have mild to severe anemia and these polymorphisms are relatively frequent in the Mediterranean and Asia 3 An X linked recessive trait G6PD glucose 6 phosphate dehydrogenase deficiency also provides protection against malaria life threatening anemias can occur under certain conditions e g eating fava beans or taking certain drugs Different mutational origins led to the polymorphisms seen in the Mediterranean and Asia Evolution 12 pg 1 4 HLA associations in the Gambia the HLA alleles B53 and DR13 are relatively frequent and have been shown to provide protection from malaria AIDS and selection two major examples of AIDS causing selection on common polymorphisms in humans are as follows in these cases AIDS has not led to these polymorphisms as in the malaria selection examples above since it is much too recent a phenomenon 1 Individuals homozygous for the CCR5 32 mutation are protected from AIDS this polymorphism is largely confined to individuals with European ancestry One possible explanation for its relatively high frequency is that it may have provided protection from smallpox the myxoma virus which is a member of the poxvirus family also exploits CCR5 for infection I CCR5 32 variant in a French population genotypes A A A 32 observed numbers 795 190 expected HW 792 1 195 8 32 32 15 12 1 Total 1 000 II CCR5 32 variant in a high risk HIV negative cohort in San Francisco genotypes A A A 32 32 32 observed numbers 793 174 29 Total 996 expected HW 777 5 205 0 13 5 III CCR5 32 variant in a HIV positive cohort in San Francisco genotypes A A A 32 32 32 observed numbers 1 988 440 1 Total 2 429 expected HW 2 007 401 9 20 1 2 HLA a specific HLA alleles provide protection and b people heterozygous for a number of HLA genes there are a total of 6 classical HLA genes live longer after infection presumably these individuals have a wider immune response Selection on single gene Mendelian and quantitative traits Relative fitness the average number of offspring produced by individuals with a certain genotype relative to the number produced by individuals with other genotypes Quantitative trait determined by a large number of genes each of small effect and environmental factors e g height and weight Fig 14 12 6th and 7th Evolution 12 pg 2 Types of selection single gene traits 1 directional 2 balancing a heterozygote advantage b frequency dependent 3 heterozygote disadvantage we will not consider this case quantitative traits 1 directional 2 stabilizing 3 disruptive diversifying Single gene traits 1 directional selection leads to fixation of an allele An example would be relative fitnesses genotype AA AB BB relative fitness 1 0 0 9 0 8 which would lead to fixation of the A allele Industrial melanism is a term used to describe the evolutionary process by which initially light colored organisms become dark as a result of natural selection in an industrial environment The process takes place because the dark organisms are better concealed from their predators in habitats that have been darkened by soot and other forms of industrial pollution lead tolerance plants able to grow on lead rich soil are found in association with mines less than a century old Populations of the grass Agrostis tenuis are clearly able to evolve through changing their genotypic frequencies quickly when the environment demands it Fig 23 1 6th Similar rapid changes have now been documented for other populations of organisms 2 balancing selection balanced polymorphism 2 or more alleles are maintained in a population due to selection Both heterozygote advantage and frequency dependent selection are examples of balancing selection they both lead to a stable polymorphic equilibrium state a heterozygote advantage the heterozygote has a higher relative fitness than both homozygotes this leads to a balanced polymorphism see sickle cell anemia example below sickle cell anemia Individuals with sickle cell trait AS heterozygotes are more resistant to malaria than individuals who are homozygous AA SS individuals are also more resistant to malaria than AA individuals but they have sickle cell anemia which drastically reduces their fitness The relative fitness values in a malarial environment have been estimated as genotype AA AS SS relative fitness 0 88 1 0 0 14 The selection in this case is very strong and causes detectable deviations from HWP Genotypes AA AS SS Observed no among adults 9 365 2 993 29 Total 12 387 Observed freq among adults 0 756 0 242 0 002 Expected no among adults HWP 9 523 2 676 188 Total 12 387 Expected freq among adults HWP 0 769 0 216 0 015 Evolution 12 pg 3 other possible examples of heterozygote advantage
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