BSC 160 1nd Edition Lecture 29Outline of Last Lecture 1. Adaptive Immunity2. Errors of the immune systemOutline of Current Lecture 1. Humoral Immunity2. Cell Mediated immunity 3. T CellsCurrent LectureHumoral Immunity- Ab- IgD- Presented in B-cells- IgG- Most versatile, most abundant Ig 75%o Can cross placenta: Placental transfero Internalize tagged cellso Opsonin- Tagging cell/antigen. Key to be phagocytose - IgE- Involved in allergic reactionso Binding can bring out responses to allergensSevere allergic responseo Role in infection by Parasitic Worms. Used as sign of…Ab Diversity- Big Picture- Mutation recombine areasAb ReactionsThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.Cell Mediated ImmunityT Lymphocyteso To be functional, has to recognize antigeno Regulation of immune systemo Help deal with threats that involve our own cells- MHC I- Major histocompatibility proteins. Self- antigenso Coding regions found on chromosome 6o On all cells of body; interact primarily with lymphocytes showing CB8 protein- MHC II- Cells of immune system; present to cells containing CD4T Lymphocytes- Must know self from non-selfo Programed to death unless it is savedo Thymuso Show tolerance 3 ways (T cells)… Maturing- fit certain criteria or you die1. Clonal anergy- becoming unresponsive to antigen2. Ts (T suppressor)- Shut down immune response once antigen is dealt with3. Sequestration- Hiding stimulatory antigen in part of body that immune system doesn’t monitor2 sub populations- CD4 proteins on cell surfaceo T Helper cells (1 & 2)- Role in cell immunity, recruitment, regulation- CD8 proteins on cell surfaceo Tc- Attack other cells, but have to be activated first- B Cell Maturation- Bone marrowT cell activation- Might help to look for explanation video on
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