BSC 160 1nd Edition Lecture 28 Outline of Last Lecture 1. Inflammation2. Chapter 16Outline of Current Lecture 1. Adaptive Immunity2. Errors of the immune systemCurrent LectureCh. 16Adaptive Immunity and Errors of the Immune System-Monocytes macrophages (stimulated to become this)-Dendritic cells are a derivative of monocytes- Adaptive Immunityo Recognizes what’s being present and then educates itselfo 2 types: Make antibodies (humorial) Those that kill the pathogen (cell mediated) o Antigen Presenting Cells Macrophages, B-lymphocytes, dendritic cells (most important)- Dendrite: have fingers (looking)- They fall under 4 categories & based upon where you find themo Skino Mucus membraneso Blood streamo Lymph and solid organs (exception- we don’t find in brain, eyes, testes)- Roleso Antigen presenting Activation of adaptive immune system *These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute. Help rid of T-cells that are self-reactive They keep the B-cells that produce antibodies stimulatedo Dendrites: ONLY cells that can active a neive T-cello Lymphocytes Specificity- React with one specific antigen that can activate them even though we have a population of millions of these ----VERY SPECIFIC Memory- Have ability to respond to same antigen if it is exposed again Tolerance- we don’t react to our own antigens (we don’t react to self)o Cytokines and Chemokines (Table 16.1) Cytokine - Small, soluble proteins- Less than 30 kDe- Regulate cellular function Chemokines- Small proteins- 8-12 kDe- Alarm signals/attractants- Realease to bring cells to an area of damageo Both proteins, both soluble- Humoral Immunity (16.2- don’t get hung up in details)o B Cells (lymphocyte) Making antibodies (plasma cells) & memory- Mediate immunity 10,000-100,000 receptors on surface of cells IgD & IgM – types of antibodies we will find Once activated after clumping, it will make exact copies of itself- Called clonal expansion Clonal Expansion and Ab/Memory production- Specifity (Adaptative) Antibodies- IgM-first that are releasedo Exist in a pentimer Held together by proteinso Turns on compliment systemo 3rd most common Ig- IgA-2nd most common Igo Found as a major class of Ab in secretions (tears, mucus, saliva, collistrum)o Cerum- part of the blood that isn’t cells (ex:
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