Lecture 27 Outline of Last Lecture 1. Immune System2. Lymphatic System3. Inflammation Outline of Current Lecture 1. Inflammation2. Chapter 16Current LectureINNATE SYSTEM- Inflammation- Redness- because of increased circulationFever- Change in body’s temperature- Circulating pyrogens (proteins)- reset hypothalamus & raises temperature2 sources of pyrogens: 1. Endogenous- within cells. Are released during phagocytic events. Fall into interleukin familyIncreasing body temperature… WHY?: - Shift in temp changes how pathogen interacts with body- Reduces available iron in body. - *Increase in metabolism with higher temperature2. Exogenous- pyrogens released by pathogensPhagocytosis- Phagocytes- mobile in circulatory system (bloodstream) & lymphatic system, can move into nonvascular tissuesTo devour pathogens. Identify what to eat=Non-self 1. Detection & Finding. Recognition of non-self by shape2. Attachment3. Ingestion4. Phagolysosome formation5. Digestion & Killing. Oxygen dependent & Non-oxygen dependent6. Egestion- Show on surface7. Antigen- Presentation BSC 160 1nd Edition- Monocytes- longer lived, circulate in lymphatic tissuesChapter 16- Adaptive Immunity & Errors of the Immune SystemAntigen Presenting Cells- Most important: Dendritic. - Have “fingers” neuron like appearance- 4 categories: o Skin o Cell Membranes o Blood streamo Lymph & solid organs of body except in brain, eyes, or testes- Roles: Activation of adaptive immune systemo Educating immature T Cells- Helping get rid of T cells that are self-reactiveo Plasma B cells stimulate Keep making antibodieso Only cells to activate naïve T
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