BSC 160 Edition 1nd Lecture 28 Outline of Last Lecture 1 Inflammation 2 Chapter 16 Outline of Current Lecture 1 Adaptive Immunity 2 Errors of the immune system Current Lecture Ch 16 Adaptive Immunity and Errors of the Immune System Monocytes macrophages stimulated to become this Dendritic cells are a derivative of monocytes Adaptive Immunity o Recognizes what s being present and then educates itself o 2 types Make antibodies humorial Those that kill the pathogen cell mediated o Antigen Presenting Cells Macrophages B lymphocytes dendritic cells most important Dendrite have fingers looking They fall under 4 categories based upon where you find them o Skin o Mucus membranes o Blood stream o Lymph and solid organs exception we don t find in brain eyes testes Roles o Antigen presenting Activation of adaptive immune system These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute o Lymphocytes Specificity React with one specific antigen that can activate them even though we have a population of millions of these VERY SPECIFIC Memory Have ability to respond to same antigen if it is exposed again Tolerance we don t react to our own antigens we don t react to self o Cytokines and Chemokines Table 16 1 Cytokine Small soluble proteins Less than 30 kDe Regulate cellular function Chemokines Small proteins 8 12 kDe Alarm signals attractants Realease to bring cells to an area of damage o Both proteins both soluble Humoral Immunity 16 2 don t get hung up in details o B Cells lymphocyte Making antibodies plasma cells memory Mediate immunity 10 000 100 000 receptors on surface of cells IgD IgM types of antibodies we will find Once activated after clumping it will make exact copies of itself Called clonal expansion Clonal Expansion and Ab Memory production Specifity Adaptative Antibodies IgM first that are released o Exist in a pentimer Held together by proteins o Turns on compliment system o 3rd most common Ig IgA 2nd most common Ig o Found as a major class of Ab in secretions tears mucus saliva collistrum o Cerum part of the blood that isn t cells ex plasma o Help rid of T cells that are self reactive They keep the B cells that produce antibodies stimulated Dendrites ONLY cells that can active a neive T cell
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