BSC 160 1nd Edition Lecture 27 Outline of Last Lecture 1 Immune System 2 Lymphatic System 3 Inflammation Outline of Current Lecture 1 Inflammation 2 Chapter 16 Current Lecture INNATE SYSTEM Inflammation Redness because of increased circulation Fever Change in body s temperature Circulating pyrogens proteins reset hypothalamus raises temperature 2 sources of pyrogens 1 Endogenous within cells Are released during phagocytic events Fall into interleukin family Increasing body temperature WHY 2 Shift in temp changes how pathogen interacts with body Reduces available iron in body Increase in metabolism with higher temperature Exogenous pyrogens released by pathogens Phagocytosis Phagocytes mobile in circulatory system bloodstream lymphatic system can move into nonvascular tissues To devour pathogens Identify what to eat Non self 1 2 3 4 5 6 7 Detection Finding Recognition of non self by shape Attachment Ingestion Phagolysosome formation Digestion Killing Oxygen dependent Non oxygen dependent Egestion Show on surface Antigen Presentation Monocytes longer lived circulate in lymphatic tissues Chapter 16 Adaptive Immunity Errors of the Immune System Antigen Presenting Cells Most important Dendritic Have fingers neuron like appearance 4 categories o Skin o Cell Membranes o Blood stream o Lymph solid organs of body except in brain eyes or testes Roles Activation of adaptive immune system o Educating immature T Cells Helping get rid of T cells that are self reactive o Plasma B cells stimulate Keep making antibodies o Only cells to activate na ve T Cells
View Full Document
Unlocking...