BSC 160 1nd Edition Lecture 2 Outline of Last Lecture 1 Main Characteristics of Microbes 2 History Relevance of Microbiology Outline of Current Lecture 1 Microorganism relationships 2 Robert Koch 3 History Vaccines antimicrobial compounds Current Lecture Parasitic relationship 1 benefits 1 gets hurt Commensalism 1 benefits 1 has no impact Cows gut microbes Cow eats grass bacteria has enzymes to break down cellulose to sugar helps digest Mutualism Both benefit Biotechnology Molecular Biology Study of infectious disease Molecular basis of heredity Laboratory enzymes Antibiotics Genetic engineering Immunity insight Robert Koch Father of medical microbio Anthrax 4 Postulates Show specific microbes are for specific diseases 1 2 3 4 Microbe is only in diseased animals Isolate microbe from diseased animal grown in other culture Inject into healthy mouse Disease reproduces Isolate microbe again show be same as microbe in 2 These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Limtations 1 Some microbes can t be isolated 2 Can t be tested on humans Louis Pasteur Proved spontaneous contamination is incorrect Found wine sours because of bacteria contamination Lactic acid Boiling can destroy microbes Germ theory of disease Microbes disease Fermentation metabolism following glycosis Yeast converts sugar ethanol Pasteurize Heat until bacteria is destroyed History Vaccines antimicrobial compounds Small pox highly contagious Eradicated 1977 Mortality rate 25 adults 40 children Variolation Inoculate immune system Give mild small pox recover immune Edward Jenner Found people that work with cows that get cowpox are immune to small pox Tested on a child Attenuation Taking pathogen weakening by chemical heat treatment or pass through susceptible host repeatedly
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