MBIOS 101 1nd Edition Lecture 35 Outline of Last Lecture - Lines of Defense1. Entrance of Virus 2. Virus Control Outline of Current Lecture – 1. Cell mediated response 2. Types of immunities3. Administration of vaccines4. Types of vaccines Current Lecture – Viruses1. Vaccines are important to get2. A lot of viruses can be worse if you get them when you are older3. Viruses and immune system Ag+macrophage/dendrite goes to APCHumoral T-cell mediated Bcells T-cellsPlasma cells T cytotoxic – virus cells (kills cells that have virusin them), also works against TransplantsAntibodies (IgM, IgG, IgE..etc.) Natural Killer Cells—virus cells, transplantB memory cells T suppressor cell – shut system “off”These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.4. T cytotoxic – ravenous cells5. Natural Killer cells – ravenous cells as well, attack virus cell and transplant6. T suppressor cell shut system off – regulates the T cytotoxic and natural killer cells 7. There are particular times that you get vaccines a. Certain windows of time that they are more effective b. The antigen educates your immune system for life 8. HPV virus and vaccinea. Does not prevent cervical cancerb. First made for womenc. Then males wanted it d. Epithelial cells are different for males and females and so they had to make a new vaccine9. Immunitiesa. Active – get the diseaseb. Passive – mother to babyc. Artificial – vaccinesd. Passive artificial – accidently coming in contact with a disease, Doctor gives you a gamma globulin in case you acquired the disease, gives your immune system a jump start 10. Requirements for an Effective Vaccinea. It should have low level of adverse side effects or toxicity and not cause serious harm b. It should protect against exposure to natural, wild forms of pathogenc. It should stimulate both b cells (antibody) response and cytotoxic (t cells) response d. Long-term lasting effects (produce memory)e. Not require numerous does or boosters f. Inexpensive, have a relatively long shelf life and be easy to administer 11. Multiple types of administrationa. Injection- subcutaneous SQ b. Nasal spray c. Orald. Injection- Intramuscular IM 12. Types of vaccinesa. Whole bacteria – killedb. Whole bacteria – live but attenuated c. Whole virus – killedd. Whole virus – live but attenuated e. Toxoids toxins – exotoxins i. Inactivated with formaldehyde f. Subunit vaccine i. Parts of organism ii. Ag produced via bacteria and genetically
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