MBIOS 101 1nd Edition Lecture 30 Outline of Last Lecture - Lines of Defense1. Redness2. Swelling3. Pain4. Heat5. 3rd line of DefenseOutline of Current Lecture – 1. Overview of third line of defense 2. Types of Blood3. Five classifications of immunoglobulin Current Lecture – First Line of Defense1. Overview of 3rd line a. Antigens release chemical cues that travel to t-cells or b-cellsb. Either the T-cell or B-cell will replicatec. B-cells (humoral immunity – secretion of antibodies by plasma cells)d. Divides into b-memory cell or plasma cells produce antibodies (Ab)e. T-cells (Cell-mediated – attack on infected cells)2. Five classes of immunoglobulinsa. IgM (pentamer) i. First time you have seen this antigen ii. Blood type is a IgM mediated response iii. Blood types 1. Type Aa. IgM – Bb. A- antigen surface markers2. Type B a. IgM – Ab. B- antigen markers3. Type ABa. Both A and B antigen surface markersThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.b. No IgM – ABc. Universal receiver 4. Type O a. No surface markersb. IgM – Ab against Type A and Type B and Type AB bloodc. Universal giver iv. Blood type is a genetic factorv. It is essential for an individual to receive the correct blood vi. If the wrong blood is transfused in then the new blood blows up because it is attacked by the body1. Since we are transfusing so much blood, this can be lethal2. We did not figure this out until the last 100 yearsb. IgG- 2nd, 3rd ….15th time it will be seeni. Memory cell ii. Example: Puppy Process of when antibodies kick in IgG from Mom IgG 24 hrs ~1 wkIgG 16 wksIgM 8 wksBorn timeABIgM rabies Rabies (1st time seeing rabies) and last boosters (has seen before); b memory booster
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