MBIOS 101 1nd Edition Lecture 34 Outline of Last Lecture - Lines of Defense1. History of Viruses 2. Virus Characteristics Outline of Current Lecture – 1. Entrance of Virus 2. Virus Control Current Lecture – Viruses1. Viruses are very particular on what cells they infect 2. Receptor mediated endocytosis a. Locks onto cellb. The cell envaginatesc. The virus enters the cell 3. Some viruses can enter human cell because on something on the cell surface and some cannot 4. Viruses enter cell and take over what is going on inside your cell 5. Virus can create a sort of slide and go directly into the nucleus through the cytoplasm 6. RNA and DNA virusa. RNA replicate in cytoplasmb. DNA replicate in nucleusc. This is the only difference, otherwise they operate the same 7. Bacteriophage a. Use these to target certain diseases b. Two routesi. Lytic cycle 1. Bacteria lands on bacteria2. Shots in nucleic acid3. Makes parts 4. Releases the virusii. Latent (Shingles, rabies, chickenpox can all enter these stages)1. Enters bacteria 2. Enters DNA of bacteria3. Bacteria replicates These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.4. New cells have viral DNA as well c. Anti-viral drug (attack life cycle)i. Block attachment or entry of virus1. Ex. Tamiflu – flu (this drug lessens the symptoms of the flu and does not cure it—but you have to give the medicine within 24 hours of getting the symptoms) ii. Block viral uncoating1. Ex. Amantidine – Flu2. Timing is everything for this one as well iii. Stop nucleic acid synthesis (RNA or DNA)1. Ex. Acyclovir –Herpes 2. AZT – HIV iv. Stop Reverse transcriptase 1. Ex. AZT- HIV v. Stop assembly of virus particle 1. Ex. Protease – HIV vi. Stop release of virus particle 1. Ex. Tamiflu – flu2. Amantidine – Flu d. Other methods of controli. Educationii.
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