MBIOS 101 1nd Edition Lecture 27 Outline of Last Lecture - Lines of Defense1. STDs2. Reproductive tract3. Urinary Tract4. 2nd line of defense a. BloodOutline of Current Lecture – 1. RBC2. WBCa. Neutrophilsb. Basophilsc. Eosinophils d. Macrophagese. Police CellsCurrent Lecture – First Line of Defense1. Blood a. RBC -- Blood Smeari. Look at how a new RBC starts with a nucleus (starts in bone marrow) ii. goes to the spleen/liver iii. Body takes away nucleus (stays 3 days)iv. Only last 120 daysv. Liver and spleen recycle and break down the RBC vi. Blood smear can be a good indicator of your health 2. Platelets – fractionated cella. Not activated until there is a reason to be activated (flows in blood stream inactivated)b. That’s why you look for number of platelets in a blood smearc. Forms blood clots when activated d. Chemical signals cause them to activate e. Become stickyf. Look like a net over a cut These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.g. Pile up –form blood clot h. Aspirin – blood thinner and makes clotting take longer i. Fish oil is also a blood thinner and makes the clotting process take longer 3. WBC – White Blood Cellsa. Specific jobs b. Different types of WBCsi. Neutrophils 1. Phagocytes (bulk eating)2. Attack bacteria that get past the first line of defense3. Neutrophils love to eat bacteria, but can eat anything4. Realizes that that substance is foreign 5. Engulfs the material6. Brings in lytic enzymes to destroy material 7. The debris is released 8. Their cell membrane is able to reach out and grab it (by means of pseudo arms)ii. Basophils1. Function in inflammatory events 2. Works with IgO + IgM 3. Involved in inflammation iii. Eosinophils1. Active in worm and fungal infections, allergy, and inflammatory events2. Love to work against parasite 3. Shot lytic enzymes into parasite4. Attack fungal infections5. cause allergic reaction (not primary job)6. works with inflammation iv. Macrophages 1. Largest phagocytes 2. Crosses the intestine lining and enter abdominal cavity and cleans3. Can travel through tissue so it is usually the first at the injury site, can also go across blood/brain barrier 4. Aggressive WBC/phagocytes5. Removes dirt, dead cells, damaged tissue, etc. at injury site6. Send out chemical signals to get more macrophage to location7. As they are cleaning up, they release the debris and more macrophages to clean up debris 8. TB hides in macrophage and replicates 9. Activates 3rd line of Defense a. Then takes part of Ag and places it on the surface of itself (the macrophage)b. Now it is an antigen presenting cellc. Turns on 3rd line of defense v. Police Cells 1. Surveys body for foreign item 2. Can leave blood vessel3. Crawls around body cavity and
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