MBIOS 101 1nd Edition Lecture 28 Outline of Last Lecture - Lines of Defense1. RBC2. WBCa. Neutrophilsb. Basophilsc. Eosinophils d. Macrophagese. Police CellsOutline of Current Lecture – 1. MAST cells2. Dendritic cells3. Tubes of Blood 4. Inflammation Current Lecture – First Line of Defense1. MAST Cells – release histaminesa. Causes allergic reactionb. Also causes cells to leak – runny eyes, runny nose c. Specialized tissue cells similar to basophils that trigger local inflammatory reactions d. Find in skin and nose e. Involved in inflammation and allergic reactionf. Composed of granules g. Become activated degranulate histamine cause cell leakage (runny eyes, nose and swelling (think insect bite)) 2. Dendritic cells a. Found in tissueb. Process foreign material c. Present to 3rd line of defense d. Also an APC (Antigen presenting cell) e. The cell eats the antigen and then puts it on its cell wall 3. Tubed blood – blood in tubea. Normal: amount of RBC = amount of yellow plasma and a thin buffy coat in between b. Low RBC, normal buffy coat, normal amount of yellow plasma – anemic These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.c. Low RBC, thin buffy coat, pink plasma – something is hurting spleen or liverd. Normal RBC, normal plasma, thick buffy coat – maybe leukemia, maybe parasitic infection 4. Inflammation a. Acne, wounds, etc. b. Something got into your body and your body is trying to wall it offc. Creates an abscessd. Capillaries constrict to limit flowe. Puss inside absecessf. Collagen and WBC surround g. Extremely complexh. Involvesi. Blood cellsii. Chemotactic effectsiii. Chemical signals iv. Cytokines v. Cell-cell communication vi. Yes cells talk to each other i. Goals:i. Want to activate the second line of defense and the 3rd line of defense ii. Turn on using macrophages, dendritic cells, basophilsiii. Start tissue repairiv. Clean up debris, dead cells, harmful stuff v. Destroy microbes, block further invasion and spread of microbesj. Four signs:i. Painii. Swellingiii. Redness iv.
View Full Document
Unlocking...