MBIOS 101 1nd Edition Lecture 29 Outline of Last Lecture - Lines of Defense1. MAST cells2. Dendritic cells3. Tubes of Blood 4. Inflammation Outline of Current Lecture – 1. Redness2. Swelling3. Pain4. Heat5. 3rd line of DefenseCurrent Lecture – First Line of Defense1. Four Cardinal signs of Inflammation a. Rednessi. Increased blood flow blood clot (Vit K required, platelets, and 13 proteins), RBC, & WBCii. Increased WBCsiii. Increased nutrientsiv. Increased temperaturev. Increased cellular activity vi. Inflammatory mediators released 1. MAST cells – histamines vii. Repair starts viii. Vasodilation and vasoconstriction b. Swelling – Histamine i. Increased fluid These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.ii. Lymph fluid iii. Cells releaseiv. Cells go to site – WBC, RBC, plateletsv. Fluid –1. Dilute debris2. Deliver cells3. Apply pressure on nerves (pain)vi. Stop movement of microbes through tissue or blood c. Pain i. Alert there is a problem ii. Serotonin release – increase in pain receptorsiii. Interferon release – increase in pain receptors d. Heat i. Increased temperature from cellular activity ii. Increase in WBC activity – increase in phagocytosis 1. Move to cite iii. Inhibit bacterial growth iv. Kills some bacteria v. Increase healing/repair – Lance Abscess (pus pocket)vi. Increase in cell cycle vii. Increase clean up of mess- scab-dead blood clot 2. Turn on the 3rd line of defense a. Macrophages – APC (Antigen Presenting Cell)b. Dendritic Cells – APC (Antigen Presenting Cell)3. 3rd line of defensea. Specific immune response b. humoral B cells and antibodyc. Cell mediated – T – cellsd. Specific immune responsei. Loof for antigen (Ag)ii. Make Antibody (Ag) against Agiii. Label/mark Ag with Abiv. Destroy Agv. Remember the Ag
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