BSC 160 1nd Edition Lecture 33 Outline of Last Lecture 1 Infections 2 Invasions 3 Diseases to know Outline of Current Lecture 1 Streptococcal Disease 2 Tuberculosis 3 Influenza Viruses Current Lecture Streptococcal Diseases Method of pathogenesis Fimbrae Exoenzyme for invasion movement beyond attachment Capsules similar to host s own components hides bacteria o Complement system is about antibody binding bringing about changes Causing hole Antibodies don t recognize capsules Complement system not as effective Creation of super antigen toxin able to bind to regions other than antigenic site and still stimulate T cells Controlled response to specific antigen o 1 5 T cells activated by these antigens Treatment Penicillin vaccine Staphylococcus aureus Microbe Gram disease method of pathogenesis treatment Mycobacterium Tuberculosis 1900 s major cause of death in humans 100 of population infected 25 dying Large rod motile hydrophobic Obligate anaerobe has to have air Slow growth generation time is 15 20 hours Grows reproduces in extracellular fluid macrophages Difficult to detect and treat Method of Pathogenesis Does NOT have classic virulence factors Enters phagocytes Lets it get eaten doesn t go away Synthesizing highly negative recharged sugar coat prevents fusion of phagosome and lysosome Antibiotics are repelled bc so hydrophobic antibodies repelled Capable of killing macrophage it is in Treatment No single treatment 6 9 month treatment 95 cure rate 4 drugs drug synergy Vaccine injection prevents from getting disease but not infection If been vaccinated positive reading on TB test 60 80 effective Clostridium sp Corynebacterium diptheriae Microbe disease pathogenesis treatment Fungal Infections Cold and Flu Viruses Infection Nose Common Cold most common viral infection Colds per year 1 Billion 2 3 days after infection runny nose headache Go away after about 9 days Protein capsid SSRNA Small simple Treatment Let cold run its course over the counter meds to feel better No vaccine Vitamin C doesn t make a difference Repiratory Tract mucosa Influenza Viruses 1 Type A Organized into diff types based on what HA it has And what NA it has H1N1 Mostly respiratory disease Fall Winter 42 hour incubation period If completely unprotected not common cold Pig fever chills muscle aches can become lower respiratory 2 Type B 3 Type C Treatment Supportive care Antiviral drugs depends on when exposed when you have access to them
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