BSC 160 1nd Edition Lecture 31 Outline of Last Lecture 1 Immune Response 2 Allergic reactions Outline of Current Lecture 1 Hypersensitivity Current Lecture Type 3 hypersensitivity When things go wrong Don t get adequate clearing Get accumulation of antibody complexes o Repressed immune system Chronic infection Not enough monocytes to clear constant renewal Weak response o Antibodies that actually recognize self antigens Rheumatoid arthritis accumulation in joints o Chronic exposure to antigen Self mediated hypersensitivity T cells responding to allergen no circulating antibodies no induction of humoral response When having an allergic reaction initial exposure memory do not react to proteins Second response reaction When things go wrong Autoimmune Diseases 1 Genetic predisposition some disease need these Increases probability of being susceptible 2 Microbio infections can bring on disease 3 Endocrine hormones change severity of autoimmune response Lupus 4 Stress in neurotransmitters Can bring about physiological change in immune system Can contribute and enhance autoimmune disease Can bring about larger attacks on the body Chapter 18LOOK BACK on Chapter 14 NEED TO KNOW Pathogen finding a host invading host virulence factors Endotoxins exotoxins Finding a susceptible host Transmission Movement from infected host to susceptible host Direct Direct contact Physical contact Ex coughing kissing sex o Droplets spit mucus one meter or less o Aerosols can survive long distances Portal of entry respiratory tract breathe in Indirect Infected host intermediate Another host Intermediate Vehicle Vector born transmission External surface of vector Internal inside vector Patterns of Infection Localized infection pathogen enters and stays in certain area of tissues Systemic infection pathogen enters and travels through fluids in body Focal infection Localized infection breaks loose and carried to other tissues L S
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