Multilayer MicrofluidicsI. Introduction (Chen & Jia)A. Problem Definitioni. To use microprocessing techniques to address the problems associated with multi-level channel routing in bio-micro fluidic applications.B. Problem Scopei. Requirementsa. To make a multi-level micro fluidic deviceb. To integrate the device with a simple packaging solutionc. To incorporate active control elements to manipulate fluid flowii. Constraints/ Assumptionsa. Externally pumped fluid flow: No need to design on-chip pumpingb. Neglect the bio-chemistry at the test sites: Only consider how the fluid is to be transportedC. Initial Materials Informationi. Reasons for narrowing the list of potential materialsii. Overview of the mechanical and electrical properties of each materialiii. Process considerations for each type of materialD. Initial literature research resultsi. Discussion of the predominate designs and processes currently researcheda. Valvesb. Channel routingc. Electrical Connectionsd. Electrokinetics, etc.ii. Conclusions drawn from initial literature researchE. Device Design Overviewi. Brief summary of each Device Design Stage up to the final design SelectionII. Device Design StagesA. Stage 1: Initial Microchannel Test Design (Anne, Susan, & Kunal)i. Objective: To test the feasibility of a Multi-level microfluidic systemii. Device Logiciii. Device Dimensions and Geometryiv. Materialsv. Processing Method with Mask Designvi. Additional Issuesvii. Manufacturing Results: Noneviii. Experimental Results: Noneix. Summary from Stage 1 and Transition to Stage 2B. Stage 2: Modified Microchannel Test Designi. Objective: To adapt the initial Microchannel Test Design to fit within the existing packaging parametersii. Device Logiciii. Device Dimensions and Geometryiv. Materialsv. Processing Method with Mask Designvi. Additional Issuesvii. Manufacturing Results (Dan & Mark)viii. Experimental Methods & Results (Dan & Mark)ix. Summary from Stage 2 and Transition to Stage 3C. Stage 3: Pressure Actuated Valve Test Design (Shawna, Charles,& Bryan)i. Objective: To integrate an active control element into a basic microchannel design based on Stage 2.ii. Device Logiciii. Device Dimensions and Geometryiv. Materialsv. Processing Method with Mask Designvi. Additional Issuesvii. Manufacturing Results (Dan & Mark)viii. Experimental Methods & Results (Dan & Mark)ix. Summary from Stage 3III. Future alternative designsA. Fluid and control logic (Shawna)B. Materials and methodsi. SU-8ii. Acrylic (TBD)iii. AlignmentC. Valves (Susan, Kunal,Charles)i. PZT actuatedii. Bubble actuatedIV. Project ResultsA. Preferred design elements-what worked(Bryan)i. Channelsii. Valvesiii. Scaling (n + 1 layer)B. Preferred methodologiesi. Processesii. Tools (software, etc.)iii. Fabrication and testingC. Team organization and developmenti. Process flowii. Areas of improvementV. ConclusionVI. ReferencesVII. AppendixA. Gantt chartB. Minutes of the MeetingsC. Outline of Major group decisionsMultilayerMicrofluidicsOutline Assignment Key:Chen, JiaAnne, Susan, KunalShawna, Charles, BryanDan, MarkMisc.I. Introduction (Chen & Jia)A. Problem Definitioni. To use microprocessing techniques to address the problems associated with multi-level channel routing in bio-micro fluidic applications.B. Problem Scopei. Requirementsa. To make a multi-level micro fluidic deviceb. To integrate the device with a simple packaging solutionc. To incorporate active control elements to manipulate fluid flowii. Constraints/ Assumptionsa. Externally pumped fluid flow: No need to design on-chip pumpingb. Neglect the bio-chemistry at the test sites: Only consider how the fluid is tobe transportedC. Initial Materials Informationi. Reasons for narrowing the list of potential materialsii. Overview of the mechanical and electrical properties of each materialiii. Process considerations for each type of materialD. Initial literature research resultsi. Discussion of the predominate designs and processes currently researcheda. Valvesb. Channel routingc. Electrical Connectionsd. Electrokinetics, etc.ii. Conclusions drawn from initial literature researchE. Device Design Overviewi. Brief summary of each Device Design Stage up to the final design SelectionII. Device Design StagesA. Stage 1: Initial Microchannel Test Design (Anne, Susan, & Kunal)i. Objective: To test the feasibility of a Multi-level microfluidic systemii. Device Logiciii. Device Dimensions and Geometryiv. Materialsv. Processing Method with Mask Designvi. Additional Issuesvii. Manufacturing Results: Noneviii. Experimental Results: Noneix. Summary from Stage 1 and Transition to Stage 2B. Stage 2: Modified Microchannel Test Designi. Objective: To adapt the initial Microchannel Test Design to fit within the existing packaging parametersii. Device Logiciii. Device Dimensions and Geometryiv. Materialsv. Processing Method with Mask Designvi. Additional Issuesvii. Manufacturing Results (Dan & Mark)viii. Experimental Methods & Results (Dan & Mark)ix. Summary from Stage 2 and Transition to Stage 3C. Stage 3: Pressure Actuated Valve Test Design (Shawna, Charles,& Bryan)i. Objective: To integrate an active control element into a basic microchannel design based on Stage 2.ii. Device Logiciii. Device Dimensions and Geometryiv. Materialsv. Processing Method with Mask Designvi. Additional Issuesvii. Manufacturing Results (Dan & Mark)viii. Experimental Methods & Results (Dan & Mark)ix. Summary from Stage 3 III. Future alternative designsA. Fluid and control logic (Shawna)B. Materials and methods i. SU-8ii. Acrylic (TBD)iii. Alignment C. Valves (Susan, Kunal,Charles)i. PZT actuatedii. Bubble actuatedIV. Project ResultsA. Preferred design elements-what worked(Bryan)i. Channelsii. Valvesiii. Scaling (n + 1 layer)B. Preferred methodologies i. Processesii. Tools (software, etc.)iii. Fabrication and testingC. Team organization and developmenti. Process flow ii. Areas of improvementV. ConclusionVI. References VII. AppendixA. Gantt chartB. Minutes of the Meetings C. Outline of Major group