FDNS 4600 1st Edition Lecture 44Outline of Past Lecture I. McCann studyII. Proposed Treatments of ADHDOutline of Current LectureI. Usual Caffeine Intake and HealthII. Effects on DiseasesIII. PregnancyIV. High Caffeine Intake and HealthV. Caffeine and AlcoholCurrent LectureI. Usual Caffeine Intake and Healtha. Usual depends on the personb. A typical coffee drinker will usually drink 3-5 cups per day or up to 400 mg/d of caffeinec. It does not increase risk of major chronic diseasesd. Does decrease risk type 2 diabetes, CVD, cancer of liver and endometrium for healthy adultsII. Effects on Diseasesa. Cardiovascular Diseasei. CVD risk1. Moderate consumption of caffeinated coffee = 12% lower riskii. CHD risk1. Found 10% lower risk with moderate coffee consumption howeverthere are inconsistent resultsiii. Stroke risk1. Inverse associations between coffee intake and risk (as coffee intake goes up, risk goes down)2. About 8-13% lower risk 3. Complex issue iv. Blood pressure1. Mixed resultsv. Blood lipidsThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.1. When its not filtered, increased total cholesterol and LDL-cholesterol 2. When its filtered, there are minimal effect on serum cholesterol levelsvi. Atrial fibrillation risk1. Higher amounts of caffeine have no association with riskvii. Heart failure risk1. Inversely associated with riskb. Type 2 Diabetesi. Protective associationsii. For coffee consumption1. 33% lower risk for 6 c/day2. 37% lower risk for 10 c/dayiii. For decaffeinated coffee1. 36% lower risk for moderate consumptioniv. For caffeine1. 8% lower risk for every 140 mg/dv. Acute (short term large doses) caffeinated coffee consumption1. Increases blood glucose concentrations and insulin secretions2. Decreases insulin sensitivityvi. Main point is coffee and caffeine are protective!c. Canceri. Total cancer1. 13% lower risk for coffee drinkersii. Lung cancer1. 27% higher risk for Higher levels of coffee consumption 2. Possibly because people smoke with their coffeeiii. Liver cancer1. 40-50% lower risk of coffee consumptiond. Neurodegenerative Diseasesi. Parkinson’s Disease1. Inverse association between caffeine intake and riskii. Alzheimer’s Disease1. Caffeine intake associate with moderately lower risk of cognitive decline or impairment and lower riskIII. Pregnancya. Concern that caffeine is involved with issuesi. Preterm delivery risk1. Moderate caffeine intake not associated with riskii. Miscarriage, stillbirth, low birth weight, small for gestational age births1. Higher intake caffeine intake associated with increased riskiii. Implications1. Limit caffeine intake to no more than 200 mg caffeine per day or ~2 c/dIV. High Caffeine Intake and Healtha. High intakei. >400 mg/d caffeine for adultsii. Undetermined for children and adolescentsb. Energy drinks increase caffeine toxicity and cardiovascular eventsc. Caffeine may mask alcohol intoxicationV. Caffeine and Alcohola. Caffeinated Alcoholic Beveragesi. Caffeine and alcohol premixedii. Usually have higher alcohol content than beeriii. FDA banned CAB in 2010- not GRASb. Myth- caffeine and alcohol counter effectsc. Truth- Caffeine increases desire to drink more alcohol and reduces caffeine reduces ability to accurately perceive alcohol intoxication.i. 3x more likely to binge
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