FDNS 4600 1st Edition Lecture 44 Outline of Past Lecture I II McCann study Proposed Treatments of ADHD Outline of Current Lecture I II III IV V Usual Caffeine Intake and Health Effects on Diseases Pregnancy High Caffeine Intake and Health Caffeine and Alcohol Current Lecture I II Usual Caffeine Intake and Health a Usual depends on the person b A typical coffee drinker will usually drink 3 5 cups per day or up to 400 mg d of caffeine c It does not increase risk of major chronic diseases d Does decrease risk type 2 diabetes CVD cancer of liver and endometrium for healthy adults Effects on Diseases a Cardiovascular Disease i CVD risk 1 Moderate consumption of caffeinated coffee 12 lower risk ii CHD risk 1 Found 10 lower risk with moderate coffee consumption however there are inconsistent results iii Stroke risk 1 Inverse associations between coffee intake and risk as coffee intake goes up risk goes down 2 About 8 13 lower risk 3 Complex issue iv Blood pressure 1 Mixed results v Blood lipids These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute III 1 When its not filtered increased total cholesterol and LDLcholesterol 2 When its filtered there are minimal effect on serum cholesterol levels vi Atrial fibrillation risk 1 Higher amounts of caffeine have no association with risk vii Heart failure risk 1 Inversely associated with risk b Type 2 Diabetes i Protective associations ii For coffee consumption 1 33 lower risk for 6 c day 2 37 lower risk for 10 c day iii For decaffeinated coffee 1 36 lower risk for moderate consumption iv For caffeine 1 8 lower risk for every 140 mg d v Acute short term large doses caffeinated coffee consumption 1 Increases blood glucose concentrations and insulin secretions 2 Decreases insulin sensitivity vi Main point is coffee and caffeine are protective c Cancer i Total cancer 1 13 lower risk for coffee drinkers ii Lung cancer 1 27 higher risk for Higher levels of coffee consumption 2 Possibly because people smoke with their coffee iii Liver cancer 1 40 50 lower risk of coffee consumption d Neurodegenerative Diseases i Parkinson s Disease 1 Inverse association between caffeine intake and risk ii Alzheimer s Disease 1 Caffeine intake associate with moderately lower risk of cognitive decline or impairment and lower risk Pregnancy a Concern that caffeine is involved with issues i Preterm delivery risk 1 Moderate caffeine intake not associated with risk ii Miscarriage stillbirth low birth weight small for gestational age births 1 Higher intake caffeine intake associated with increased risk iii Implications IV V 1 Limit caffeine intake to no more than 200 mg caffeine per day or 2 c d High Caffeine Intake and Health a High intake i 400 mg d caffeine for adults ii Undetermined for children and adolescents b Energy drinks increase caffeine toxicity and cardiovascular events c Caffeine may mask alcohol intoxication Caffeine and Alcohol a Caffeinated Alcoholic Beverages i Caffeine and alcohol premixed ii Usually have higher alcohol content than beer iii FDA banned CAB in 2010 not GRAS b Myth caffeine and alcohol counter effects c Truth Caffeine increases desire to drink more alcohol and reduces caffeine reduces ability to accurately perceive alcohol intoxication i 3x more likely to binge drink
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