FDNS 4600 1st Edition Lecture 36 Outline of Past Lecture I II III IV V VI VII Regulation of Color Additives Certified Color Additives Approved Certified Colors Possible Mechanisms for Certified Color Reactions Behavior Allergy Other Stevens LJ Nutr Rev 2014 Food Flavors Safety assessment Issues and Challenges Outline of Current Lecture I II III IV V Use of MSG Is MSG a Food Allergen Children Pregnancy and Lactation Chinese Restaurant Syndrome MSG Challenge Study Current Lecture I II III Use of MSG a Umami savory meat taste b Major use is it is a flavor enhancer c Helps reduce sodium intake d The elderly or hospitalized people are most likely to have benefit form it makes it easier to eat and has lower sodium Is MSG a Food Allergen a From a review in 1991 the answer is NO i It was a double blind placebo controlled experiment where people consumed 2 5 grams MSG daily b In relation to Asthma i Linked in poorly controlled studies Children Pregnancy and Lactation a Some people think that it might have a negative effect on children but it is not true i Children metabolize MSG slower than adults NO These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute IV V ii Role in ADHD other behavior disorders NO b Pregnancy i In fetus amino acid concentrations are higher in fetus regardless of mother s intake ii Placenta helps block glutamate entry iii No adverse effects in studies c Lactation i No increase in glutamate in breast milk ii No effects on infant Chinese Restaurant Syndrome a Not proven b Reported anecdotal symptomsc Real concerns with Chinese food i Increased sodium intake ii Increased calorie intake MSG Challenge Study a Rationale i Some people reported headaches facial burning and abdominal pain after ingestion ii But there could be problems with validity of these studies b Methods i Recruitment 1 Newspapers prior reaction to Asian food ii Telephone screening 1 Had to have more than 2 of the 10 symptoms and be 18 60 years old c Protocol A i The MSG group had the biggest reaction ii The Neither group meaning there was no reaction had the next largest group d Protocol B i The people who had more than 2 symptoms in Protocol A moved on to Protocol B ii The graph shows the largest reaction was in the group that was feed 5 g of MSG and then decreased in order of amount given to them e Protocol C i The people in this group had to 2 positive reactions to 5 g MSG in A and B but not to placebo ii The sample size was 12 people and nine people showed symptoms f Protocol D i Only two people qualified ii Results from the study 0 reproducible symptoms last column on chart
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