FDNS 4600 1st Edition Lecture 12 Outline of Past Lecture I II Gluten free labeling HEALTH CLAIMS Outline of Current Lecture I Research Methods II What We Eat and Drink III Safety and Efficacy IV Case report the case of the egg man V Meta analysis of cohort studies Current Lecture I II III IV Research Methods a Case reports usually a single person b Case series all studies are leading in the same direction c Cross sectional studies a lot of people and measure what they are eating and seeing the issues they have d Case control studies studies people with a certain condition and a control group to see difference e Cohort studies large group of people and follow them over time f RCT Randomize Control Test randomly assign to groups g Systematic reviews meta analyses combined types of research h Policy analysis use data to create policy i In the Hierarchy of Evidence the top is where the most solid research is What We Eat and Drink a Toxins intrinsic to the food can be dangerous in some doses b Contaminants toxic but its not supposed to be there yet it is Safety and Efficacy a Biomarkers way to tell if something is dangerous or not Case report the case of the egg man a Normal cholesterol is 200 mg dl b How can we use this study to determine whether eggs influence serum cholesterol i This is just one person so it does not reflect the population These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute VI ii Not applicable because a usual person does not eat 20 30 eggs per day iii This case is an extreme outlier Meta analysis of cohort studies a Looked for studies all over the world and processed them to find studies that would be useful to analyze b Had 8 different research studies included in the study i In risk for coronary heart disease study found that if the relative risk RR is one it would be the same if a person was eating eggs or not 1 The more eggs you eat does not increase your risk because the best fit line is flat and not increasing ii Stroke RR 1 means there is no risk 1 The best fit line is decreasing but is not statistically sound to prove eggs help but it shows they did not harm iii Conclusion eggs are not associated with risk of coronary heart diseases or strokes
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