BIOL 101 1nd Edition Lecture 16 Outline of Last Lecture I. ApplicationII. PedigreesIII. Problems involving PedigreesOutline of Current Lecture I. DNA Structure and FunctionII. Three teamsIII. The Race to Find DNAIV. Current LectureDNA Structure and FunctionClass discussion1. Three teams were racing. Who were the team members of each team? What technique did each use?1. Watson and Crick – make physical models to narrow down the possibilities and eventually create an accurate picture of the molecule2. Pauling – had already won 2 nobel prizes and began to research DNA, he took pictures as well 3. Rosalind Franklin and Wilkins – experimental approach, looking particularly at x-ray diffraction images of DNA.2. What experiments did Watson and Crick specialize in that helped them solve the structure of DNA?They had worked with proteins which helped them realize that DNA was an antiparallel double helix. 3. What did Franklin think of model building?her view was you could build models all day and you could probably generate as many models as you had time for hot dinners. But how did you prove which one was right?4. What was the conflict between Wilkins and Franklin?Wilkins thought Franklin was just a technical assistant but that was not how Franklin thought which caused conflict between them. These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.6. Describe Chargaff’s rules.Chargaff's rules state that DNA from any cell of all organisms should have a 1:1 ratio (base Pair Rule) of pyrimidine and purine bases and, more specifically, that the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine. This pattern is found in both strands of the DNA.What did Chargaff think of Watson and Crick?He extremely disliked them.7. What did the “X” pattern on Franklin’s crystallography image indicate?The distinctive "X" in this X-ray photo is the telltale pattern of a helix. Because the X-ray patternis so regular, the dimensions of the helix must also be consistent. For example, the diameter of the helix stays the
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