BIOL 101 1nd Edition Lecture 16 Outline of Last Lecture I Application II Pedigrees III Problems involving Pedigrees Outline of Current Lecture I DNA Structure and Function II Three teams III The Race to Find DNA IV Current Lecture DNA Structure and Function Class discussion 1 Three teams were racing Who were the team members of each team What technique did each use 1 Watson and Crick make physical models to narrow down the possibilities and eventually create an accurate picture of the molecule 2 Pauling had already won 2 nobel prizes and began to research DNA he took pictures as well 3 Rosalind Franklin and Wilkins experimental approach looking particularly at x ray diffraction images of DNA 2 What experiments did Watson and Crick specialize in that helped them solve the structure of DNA They had worked with proteins which helped them realize that DNA was an antiparallel double helix 3 What did Franklin think of model building her view was you could build models all day and you could probably generate as many models as you had time for hot dinners But how did you prove which one was right 4 What was the conflict between Wilkins and Franklin Wilkins thought Franklin was just a technical assistant but that was not how Franklin thought which caused conflict between them These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute 6 Describe Chargaff s rules Chargaff s rules state that DNA from any cell of all organisms should have a 1 1 ratio base Pair Rule of pyrimidine and purine bases and more specifically that the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine This pattern is found in both strands of the DNA What did Chargaff think of Watson and Crick He extremely disliked them 7 What did the X pattern on Franklin s crystallography image indicate The distinctive X in this X ray photo is the telltale pattern of a helix Because the X ray pattern is so regular the dimensions of the helix must also be consistent For example the diameter of the helix stays the same
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