J210 Final Exam, Fall 2013 Page 1 of 12 J210 Microbiology & Immunology December 11, 2013 Final Examination - Virology This examination consists of 70 questions. Questions 1 to 35 are worth 2 points each. Questions 36 to 70 are worth 1 point each which includes 5 bonus points on this exam. A perfect score equals 105 points. You have from 8:10 am to 9:40 am. All answer sheets are due at 9:40 am, even if you arrived late. Make sure your last name and initials, are placed on the computer-graded answer sheet, and that the corresponding circles are filled in. Check to make sure you have all 12 pages. You are encouraged to write on this question sheet and retain it. An answer key will be posted on Oncourse after the exam. Once the key has been posted, questions will be discussed via Oncourse only. Results for this exam will be finalized 24 hours after the exam is completed, after which no more questions will be entertained. Final letter grades for J210 will not be posted to Oncourse. These will be made available to you by the Registrar’s office via Onestart.J210 Final Exam, Fall 2013 Page 2 of 12 Multiple Choice Questions: Select the statement which best answers the question or completes the sentence. (2 points each) 1. Which of the following is not usually associated with cancer in humans? A. Human papilloma virus B. Epstein-Barr virus C. Human T cell lymphotropic virus-1 D. Herpes simplex virus E. Hepatitis B virus 2. Which of the following vaccines should never be given to a pregnant woman? A. Hepatitis B vaccine B. MMR vaccine C. Rabies vaccine D. Flu vaccine E. All of the above 3. Which of the following signs or symptoms is not associated with viral hepatitis? A. Nausea B. Dark urine C. Jaundice D. Petechial rash E. Elevated liver enzymes in the serum 4. Naked capsid RNA virus which is the most frequent cause of the common cold. A. Respiratory syncytial virus B. Adenovirus C. Measles virus D. Rhinovirus E. Influenza virus 5. Enveloped RNA virus causing bronchitis and pneumonia, where infection is especially dangerous in premature infants with under-developed lungs. A. Influenza virus B. Coxsackie B virus C. Adeno-associated virus D. Respiratory syncytial virus E. AdenovirusJ210 Final Exam, Fall 2013 Page 3 of 12 6. Which of the following is mismatched? A. Salk vaccine – administered by injection B. Sabine vaccine – administered orally C. Salk vaccine – live attenuated polio vaccine D. Sabine vaccine – protects against all 3 serotypes of poliovirus E. Sabine vaccine – primarily used outside the USA 7. The influenza viral protein, hemaglutinin is important for which step of viral reproduction? A. Penetration of mucus layer in pharynx B. Attachment to epithelial cells C. Uncoating of nucleocapsid D. Replication of viral genome E. Budding of viral particles 8. Rotaviruses are a major cause of _____ A. Common Cold B. Viral encephalitis C. Viral gastroenteritis D. Viral pneumonia E. Viral hepatitis 9. Sub-acute sclerosing pan-encephalitis (SSPE) is an occasional delayed consequence of infection by the virus that causes which childhood disease? A. Rubella B. Fifth disease C. Measles D. Hand, foot and mouth disease E. Chicken pox 10. Which of the following is not a component of Influenza virus serotype A? A. Hemaggutinin B. Neuraminidase C. RNA D. Envelope E. Reverse transcriptaseJ210 Final Exam, Fall 2013 Page 4 of 12 11. Which of the following conditions in animals or humans is not caused by prion proteins? A. Scrapie B. Variant Creutzveld-Jacob disease C. Bovine spongiform encephalopathy D. Non-immune hydrops fetalis E. Kuru 12. A dental hygienist reports a painful rash with blistering on one of her fingers. This description is consistent with A. Chickenpox B. Roseola C. Shingles D. Herpetic whitlow E. Smallpox 13. The threshold CD4 T cell count, below which patients typically start seeing opportunistic infections associated with acquired immunodeficiency syndrome (in cells/mm3 of blood). A. 800 B. 600 C. 200 D. 50 E. 0 14. Immunity conferred by influenza vaccine typically protects the patient by preventing which of the following steps of the viral cycle? A. Attachment B. Penetration C. Uncoating D. Replication E. AssemblyJ210 Final Exam, Fall 2013 Page 5 of 12 15. A newspaper published an article about a cruiseship where about 400 passengers were, “struck down with a notorious winter vomiting bug”. The agent causing their uncomfortable affliction was likely ____ A. Rotovirus B. Coxsackievirus A C. Chicken pox virus D. Norovirus E. Hepatitis D virus 16. Common name for a childhood disease which is generally self-limiting in children, but is notorious for causing birth defects when the mother becomes infected during pregnancy. A. Seven-day measles B. Mumps C. Chicken pox D. German measles E. Hand, foot and mouth disease 17. A 25 year old man is bitten by a potentially rabid bat during a caving trip. What is the recommended procedure for the treatment of this individual? A. Immediately clean and disinfect his wound B. Passively immunize him with an injection of human rabies immune globulin C. Actively immunize him with rabies vaccine D. A and B E. A, B and C 18. Epstein Barr virus establishes latency in ___ A. Nerve cells B. Liver cells C. Mucosal epithelial cells D. B cells E. T cellsJ210 Final Exam, Fall 2013 Page 6 of 12 19. A 2 year-old boy presents at the emergency room with muscle weakness and increasing paralysis. A history reveals the boy received a flu shot about 8 weeks previously. Differential diagnosis should include the possibility of ___ A. Reyes Syndrome B. Guillain-Barre syndrome C. Orchitis D. Croup E. Herpangina 20. Agent commonly implicated in inflammation of the heart or pericardial sac. A. Adenovirus B. Coxsackievirus C. Influenza virus D. Poliovirus E. Cytomegalovirus 21. Which of the following activities currently puts people at greatest risk of contracting hepatitis C? A. Sex with multiple partners B. Frequent consumption of raw oysters C. Intravenous drug habit D. Working in a hospital E. Sharing food with an infected individual 22. An effective, long-term immunity conferring vaccine is currently not available for which of the following? A. Hepatitis A virus B. Rotavirus C. Poliovirus D. Respiratory syncytial virus E. (vaccines are available for all the above) 23. Which of