J210 Exam 2, Fall 2013 Page 1 of 12 J210 Microbiology & Immunology October 9, 2013 Examination 2 This examination consists of 70 questions. Questions 1 to 35 are worth 2 points each. Questions 36 to 70 are worth 1 point each which includes 5 bonus points on this exam. A perfect score equals 105 points. You have from 8:10 A.M. to 9:40 A.M. for this examination. All answer sheets are due at 9:40 A.M. even if you arrived late. Make sure your initials and last name, as well as your full identification number, are placed on the computer-graded answer sheet, and that the corresponding circles are filled in. An answer key will be posted on Oncourse within 2 hours following the exam. You are encouraged to write on this question sheet and retain it after the exam. Once the key has been posted, examination questions can be discussed on Oncourse. Scores will be posted to Oncourse before the weekend.J210 Exam 2, Fall 2013 Page 2 of 12 Part A: Multiple choice questions (1 through 35). Select the one answer which best answers each question. 1. Which of the following processes is associated with macrophages and not with T cells? A. Presentation of antigen combined with MHC Class II molecules B. Specific recognition of antigen C. Secretion of Interleukin-2 (IL-2) D. Maturation in the thymus E. Possession of CD4 or CD8 2. An immature macrophage is called a A. Mast cell B. Monocyte C. T-lymphocyte D. B-lymphocyte E. Neutrophil 3. Passive immunotherapy is used when A. The attenuated live vaccine is too difficult to produce B. Protection against a recent infection or disease is needed immediately C. The pathogen does not produce a toxin D. A representative antigen for the microbe cannot be isolated E. The microorganism can be genetically manipulated 4. Which cell type is associated with non-phagocytic killing of parasitic worms? A. Basophil B. Eosinophil C. Neutrophil D. Macrophage E. Lymphocyte 5. Which of the following cell types has Fc receptors that bind IgE? A. Memory T-cell B. Mast cell C. Neutrophil D. Plasma cell E. MacrophageJ210 Exam 2, Fall 2013 Page 3 of 12 6. Which immunoglobulin class can be transmitted from mother to child in breastmilk? A. IgM B. IgG C. IgA D. IgE E. IgD 7. Which complement split-protein ends up bound to pathogenic microbes and is recognized by specific receptors on phagocytes? A. C3 B. C5 C. C3a D. C3b E. C5a 8. MHC class I molecules are A. Enzymes secreted to destroy a pathogen’s cell wall B. Specific molecules, or parts of molecules, that a body recognizes as foreign C. Proteins on the surface of our cells that can display viral antigens D. Proteins the body produces against invading substances E. Cells that protect the body against invaders 9. If a man is blood type O, which of the following antibodies would be found in his serum? A. Antibodies to the A blood group antigen B. Antibodies to the B blood group antigen C. Antibodies to both the A and B blood group antigens D. Antibodies to neither blood group antigen E. Antibodies to the Rh antigen 10. Which of the following is caused by the formation of immune complexes in the bloodstream? A. glomerulonephritis due to systemic lupus erythrematosus B. Rhinitis in reaction to ragweed pollen C. Graft rejection in a kidney transplant patient D. Anaphylaxis in reaction to bee venom E. Adverse reaction to mismatched blood transfusionJ210 Exam 2, Fall 2013 Page 4 of 12 11. Which of the following cells are incapable of presenting endogenous antigens on MHC Class I molecules? A. Macrophage B. Neutrophil C. Dendritic cell D. Mucosal epithelial cell E. Red blood cell 12. The type of ELISA that is a direct assay A. Detects the presence of a particular antigen B. Uses antibody-coated beads C. Uses agglutination to determine the titer D. Detects the presence of a particular antibody E. Relies on the presence of complement 13. Under normal conditions, the adaptive immune system does not attack autoantigens because A. Lymphocytes identify cells with autoantigens as belonging to the body and do not attack them B. Antibodies prevent CTLs from binding to the body’s own cells C. Lymphocytes never have binding sites that are complimentary to autoantigens D. Lymphocytes that bind to autoantigens are selected to undergo apoptosis E. Antibodies produced against autoantigens are destroyed 14. Which type of antibody is associated with hemolytic disease of the newborn? A. IgA B. IgD C. IgE D. IgG E. IgM 15. A burn patient has healthy skin from his unburned thigh grafted to the injured site. This is known as a(n) A. Autograft B. Homograft C. Xenograft D. Isograft E. AllograftJ210 Exam 2, Fall 2013 Page 5 of 12 16. The prevalent immunoglobulin class found in blood is A. IgA B. IgD C. IgE D. IgG E. IgM 17. Which of the following recognizes and binds to MHC Class II proteins and helps stabilize the binding of presented antigenic peptides to T cell receptors? A. CD4 B. Interleukin-2 (IL-2) C. CD95 D. Interleukin-4 (IL-4) E. CD8 18. If a person with ABO blood type A is transfused with blood from a type O donor, which is the most likely outcome? A. Recipients phagocytic cells will engulf and destroy the donor red cells B. Donor red cells will survive and function normally C. Recipients cytotoxic T cells will destroy the donor red cells D. Donor cytotoxic T cells will cause graft vs host disease E. Donor red cells are lysed by recipient’s antibodies and complement 19. Which of the following processes is absolutely dependent on adaptive immunity? A. Bacterial lysis with salivary lysozyme B. Release of inflammatory mediators in response to an allergen C. Recruitment of leukocytes to an inflammatory site by complement split products D. Activation of leukocytes via Toll-like receptors E. Protection of cells by interferon-alpha and interferon-beta 20. Which of the following locations would expect to be absent of B cells? A. Spleen B. Tonsils C. Lymphatic vessels D. Thymus E. Mucosa-associated lymphoid tissue (MALT)J210 Exam 2, Fall 2013 Page 6 of 12 21. Which of the following cell types is not considered a phagocyte? A. B cells B. Neutrophils C. Dendritic cells D. Macrophages E. None of the above (all are phagocytes) 22. The perforin-granzyme pathway involves A. The production of fever which kills the pathogen B. Binding of CD95L on CTLs to CD95 on infected cells, which leads to