FA18 IN MICR J210 23053 Exam 2 Page 1 of 16 J210 Microbiology & Immunology October 10, 2018 Examination 2 INSTRUCTIONS: 1. DO NOT START THE EXAM UNTIL YOU HAVE BEEN GIVEN THE GO-AHEAD. 2. Locate your answer sheet and print your last name and first name in the boxes at the top. 3. On your answer sheet write your Student identification number in the boxes indicated and fill in the according bubbles. Make sure you use 10 digits (if your Student ID has only 7 digits, the first three would be 000). 4. Grading: Questions 1 to 35 are worth 2 points each. Questions 36 to 70 are worth 1 point each which include 5 bonus points on this exam. Points will be awarded for a single correct answer. Your score will be accumulated points (a perfect score is 105 points). 5. Both sides of this question paper are printed; make sure you answer all 70 questions. 6. You have from 8:10 A.M. to 9:40 A.M. for this exam. All answer sheets are due at 9:40 A.M., even if you arrived late. 7. An answer key will be posted on Canvas within about 2-3 hours following the exam. You are encouraged to write on this question sheet and retain it after the exam to compare your responses. Once the key has been posted, examination questions will be discussed by the Canvas Discussion forum only. 8. Individual scores will be posted on Canvas before the next class.FA18 IN MICR J210 23053 Exam 2 Page 2 of 16 Part A: Multiple choice questions (1 through 35). Select the one choice which best answers the question or completes the sentence. 1. Which of the following cytokines will attract leukocytes to an inflammatory site? A) growth factors B) tumor necrosis factors C) chemokines D) interleukins E) interferons 2. Which of the following processes is associated with macrophages and not with T cells? A) Secretion of Interleukin-2 (IL-2) B) Possession of CD4 or CD8 C) Maturation in the thymus D) Specific recognition of antigen E) Presentation of antigen combined with MHC Class II molecules 3. ____ is the first class of antibody to be produced in a humoral immune response to a specific antigen. A) IgE B) IgD C) IgM D) IgA E) IgG 4. Rheumatoid arthritis involves inflammation in the joints due to the deposition of immune complexes mostly containing ____. A) IgE. B) IgM. C) IgA. D) IgD. E) IgG.FA18 IN MICR J210 23053 Exam 2 Page 3 of 16 5. In which of the following locations would you expect to find an accumulation of long-lived IgG-secreting plasma cells? A) Tonsils B) Mucosa-associated lymphoid tissue (MALT) C) Thymus D) Spleen E) Bone marrow 6. Which of the following has receptors to bind to C3b-coated pathogens? A) mast cells B) B cells C) plasma cells D) macrophages E) T cells 7. Which of the following may result in graft-versus-host disease? A) Cornea transplant. B) Kidney transplant. C) An Rh-positive fetus in the uterus of an Rh-negative mother. D) Bone marrow transplant. E) Skin transplant from one location in the body to another or from one identical twin to another. 8. MHC class I molecules are ____. A) Proteins the body produces against invading substances B) Proteins on the surface of our cells that can display viral antigens C) Cells that protect the body against invaders D) Specific molecules, or parts of molecules, that a body recognizes as foreign E) Enzymes secreted to destroy a pathogen's cell wall 9. The most important site for removal of autoreactive T cells is the ____. A) blood vessels. B) thyroid. C) thymus. D) bone marrow. E) lymph nodes.FA18 IN MICR J210 23053 Exam 2 Page 4 of 16 10. Lysozymes are ____. A) proteins on the surface of our cells that pathogens attach to. B) enzymes secreted to destroy bacterial cell walls. C) types of antibodies which neutralize bacterial pathogens. D) cells that protect the body against invaders. E) specific molecules, or parts of molecules, that a body recognizes as foreign. 11. Which event is the immediate trigger for the formation of complement membrane attack complexes? A) Activation of the alternate pathway B) Activation of C5 convertase C) Activation of the classical pathway D) Activation of the lectin pathway E) Activation of C3 convertase 12. Which of the following induces clonal expansion of activated CD8 T cells? A) CD4 B) Interferon gamma C) Interleukin 2 D) C5a E) C3b 13. A small amount of antigen is injected under the skin of a patient. After 30 minutes there is no apparent change at the injection site, but 36 hours later the patient reports that the area is red and swollen. This type of response is due to ____. A) Type III hypersensitivity B) Type IV hypersensitivity C) Immunodeficiency D) Type I hypersensitivity E) Type II hypersensitivity 14. Antibodies are ____. A) soluble proteins the body produces against invading substances. B) enzymes secreted to destroy a pathogen's cell wall C) cells that protect the body against invaders. D) proteins on the surface of our cells that pathogens attach to. E) specific molecules, or parts of molecules, that a body recognizes as foreign.FA18 IN MICR J210 23053 Exam 2 Page 5 of 16 15. From the following list, which donor blood type can be safely transfused into an O-positive patient? A) B-negative B) AB-negative C) O-negative D) A-positive E) none of the above is safe 16. Which of the following processes is carried out by both B and T cells A) Presentation of peptides combined with MHC Class I molecules B) Maturation in the thymus C) Secretion of interleukin-2 (IL-2) D) Presentation of peptides combined with MHC Class II molecules E) Secretion of interleukin-4 (IL-4) 17. Plasma cells secreting low-affinity IgM are primarily located in the ____. A) thymus B) bone marrow C) pancreas D) bloodstream E) lymph nodes 18. The type of ELISA that is a direct assay ____. A) Uses antibody-coated beads B) Detects the presence of a particular antibody C) Detects the presence of a particular antigen D) Relies on the presence of complement E) Uses agglutination to determine the titer 19. If a person has the AB blood type, which of the following isoagglutinins would be found in that person's serum? A) Antibodies to the B blood group antigen. B) Antibodies to neither A nor B blood group antigen. C) Antibodies to the A blood group antigen. D) Antibodies to the Rh antigen. E) Antibodies to both the A and the B blood group antigens.FA18 IN MICR