10 18 Drugs 18 04 2012 17 03 00 Cocaine Comes from the coca shrub of South America Blocks the reuptake of dopamine Blocks the reuptake of norepinephrine Serotonin release causes mood elevation 15 30 minutes after administration o crash of irritability and depression o cases of depression after long term use often mixed with alcohol o they have opposite effect so when one does cocaine while drunk they feel less drunk o liver produces cocaethaline when mixed with alcohol and this send it up to the brain and creates the same cocaine effect tolerance the need of more and more of the drug to achieve the just more drastic same effect o kills off dopamine receptors on the nerve cells after long term use user s brain is desensitized they need more cocaine to produce more dopamine need cocaine to just feel normal MDMA Ecstasy Acts to increase dopamine and norepinephrine Releases serotonin and blocks its reuptake visual auditory hallucinations heightened sensitivity and sociability oxytocin release cuddle chemical hormone released o when you see your loved one come off the plane o orgasm o child mother attachment o trust experiences stimulant and milk hallucinogen which leads to emotional elevation and feeling of connectedness risk of dehydration too thirsty hyperthermia too hot hypoatremia not enough sodium because water washes it out and increased risk of damage to serotonin producing neurons Hallucinogens Alters sensory perception producing peculiar experiences and hallucinations LSD PCP psilocybin mescaline Act on serotonin receptors as an agonist DOES NOT increase dopamine levels directly Psilocybin mimics serotonin in the synapse because the shape is o Not addictive very similar Marijuana Leaves and flowers of hemp plant Active chemical in marijuana is called THC THC is known as a cannabinoid o 2 AG Anandamide endogenous cannabinoids they re already there types of receptors in the brain Anandamide appetite stimulation and decreased pain sensitivity Partly responsible for our anti stress reaction THC disrupts neurotransmitters activates almost all neurotransmitter systems o Increase glutamine o Increases endorphins o Inhibits GABA o Increases dopamine norepinephrine 18 04 2012 17 03 00 18 04 2012 17 03 00
View Full Document
Unlocking...