PSIO 201 1st Edition Lecture 7 Outline of Last Lecture I Cellular Level of Organization IV V The Nucleus and Regulation of Gene Expression Outline of Current Lecture II Cellular Level of Organization The Nucleus and Regulation of Gene Expression III Protein Synthesis A Transcription B Translation Current Lecture Transcription Synthesis of RNA to DNA Synthesis of a complimentary RNA strand using the base sequence of DNA as a template Occurs in the Nucleus and RNA strand exits nucleus through nucleus pores Contains both promoter and terminator on RNA strand RNA Polymerase enzyme that makes the RNA chain out of DNA Produces mRNA alternative splicing of exons can produce distinct mRNA Transcription Regulation Promoter Regulation is used as a mechanism for regulation of gene expression Promotor DNA sequence upstream to the start of the gene to which RNA polymerase binds Transcription factors proteins that bind to the promotor to augment binding of RNA polymerase Translation RNA base sequence as a template for protein synthesis Occurs in the cytoplasm Involves mRNA tRNA and rRNA Produces proteins when Ribosome is attached to RNA for protein synthesis Ribosome reads the RNA and mRNA binds to small sub unit These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Ribosome has two units Small and Large with two sites A to P A method of producing multiple proteins from a single RNA strand includes SPLICING The Introns are folded and exons are sliced for multiple protein codes
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