Study Guide Biochemistry 1 A B Hydrophilic vs Hydrophobic Since biological chemistry occurs largely in an aqueous environment the interaction of a biological molecule with water is very important That interaction is influenced by two primary causes size and polarity charge The smaller a molecule is the more likely it is to be willing to associate with water dissolve Also the more polar and or charged a molecule is the more likely it is to be willing to associate with water Since biological molecules are often very large it is common for the different parts of the molecule to interact differently in water For instance a protein which is composed of many different amino acids which have a large variety of characters may be hydrophobic in part of its sequence and hydrophilic in other parts Hydrophilic hydro water philios love Hydrophilic molecules or parts of molecules will dissolve in interact with water Hydrophobic hydro water phobio fear Hydrophobic molecules or parts of molecules will refuse to interact with water If sufficiently hydrophobic a molecule or part of a molecule will actively repel or exclude water Hydrophilic phobic characters are not an all or none phenomenon Molecules fall along a scale somewhere between extremely hydrophobic and extremely hydrophilic Changing the parts of a molecule will often shift it more toward the hydrophobic or the hydrophilic end of the scale depending upon the change Hydrocarbons The basic skeletons of organic molecules are composed of hydrocarbon Hydrocarbon is made only of the elements carbon and hydrogen Since carbon atoms all have the same electronegativity and the electronegativity of hydrogen is only slightly different than that of carbon the bonds in hydrocarbons are all non polar Thus hydrocarbons tend to be hydrophobic especially if they are more than a few carbons in size The many many different organic molecules are formed by attaching a variety of functional groups to hydrocarbon skeletons Each functional group has its own characteristic behavior and the combinations of the behaviors of a molecule s functional groups and the effects of the hydrocarbon skeleton create the overall nature of the molecule Classes of organic molecules are largely characterized by their functional groups C Important Functional Groups 1 2 3 4 Hydroxyl Group found in alcohols and carbohydrates This is a polar functional group due to the polar covalent bond between oxygen and hydrogen Molecules whose most influential functional group is a hydroxyl group are called alcohols and their systematic names end in ol Example ethanol Carboxyl Group found in organic acids The carboxyl is sometimes written COOH The H on the OH dissociates easily in appropriate circumstances thus liberating H a hydrogen ion and creating COO This makes this functional group a proton donor and thus acidic It also makes the carboxyl group a strong hydrophilic force Molecules whose most influential functional group is a carboxyl group are considered to be organic acids their systematic names end in ate Example acetate Amino Group The amino is sometimes written NH2 The amino group is polar due to the polarity of the N H bond It also tends to pick up an extra hydrogen ion due to the negative character or the N and the pair of uninvolved valence electrons thus becoming NH3 acceptor and thus alkaline in character It also makes it a strong hydrophilic influence Molecules whose most influential functional group is an amino group are organic bases and their names end in amine Example diphyenylamine This makes it a hydrogen Phosphate Group This functional group is always charged either 1 or 2 This makes it strongly hydrophilic in nature and influence Phosphates may be attached to organic molecules organic phosphate or unattached free or inorganic phosphate When diagramming the structures of phosphate containing organic molecules the organic phosphate is often abbreviated as a P inside a circle Free phosphate is often abbreviated Pi i for inorganic D Structures of Important Classes of Biological Molecules 1 Hydrocarbon hydro hydrogen carbon carbon These are molecules consisting of only hydrogen and carbon They come in many sizes and arrangements They may be saturated contain only single covalent bonds or unsaturated containing at least one double covalent bond They are very non olar since the C C bond and the C H bond are both completely non polar Most carbohydrates are quite hydrophobic 2 Examples ethane benzene a b c a b 2 Carbohydrates carbo hydrogen hydrate with water Carbohydrates are molecules consisting only of carbon and the components of water hydrogen and oxygen In common language most carbohydrates are sugars saccharides and their relatives They fall into several categories Monosaccharides mono one These molecules are composed of single sugar units They come in a variety of sizes depending upon the number of carbons in the sugar The most common of the sizes is the hexose hexa six which has six carbons Also of biological importance is the pentose penta five which has five carbons There are several different hexoses and several different pentoses and several may actually have the same molecular formula since the details of the arrangement of the hydrogen and the hydroxyls on the ring is important in the identity of the sugar Sugars are usually depicted in a ring form though they also have open chain forms Examples glucose a hexose ribose a pentose Disaccharides di 2 These sugars are made of two monosaccharides covalently bonded together The building of the linking bond is accomplished by dehydration synthesis the removing of the components of water from the two sugars to be bonded together for the purpose of providing unpaired electrons for the formation of the new bond Examples sucrose glucose fructose and maltose glucose glucose Polysaccharides poly many These molecules consist of long chains polymers of monosaccharides linked together by covalent bonds again formed through dehydration synthesis The long chains may branch Examples starch glycogen cellulose all glucose polymers 3 Lipids fats and oils These molecules are essentially all hydrophobic or partially hydrophobic There is quite a variety of structure among the lipids but the two best known examples are the steroids and the glycerides The steroids include such substances as cholesterol testosterone and estrogen The glycerides include the triglycerides primary storage lipids and phospholipids also called phosphoglycerides the
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