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MSU BMB 401 - Self_Assessment_Lecture_33_KEY Nucleotide_Fu (2) (1)

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Self-Assessment Lecture 33: Nucleotide Function and Synthesis1. Which of the following is NOT a use of nucleotides:a. Precursors for nucleic acid synthesis b. Prime energy source for biologic processesc. Activation of biomolecules for synthetic reactionsd. Primary source of nitrogen for amino acid synthesise. Important parts of many second messenger systems f. Source of phosphate for kinase reactions 2. Please indicate PY for pyrimidine and PU for purine, and state DNA, RNA or Both to identify the nucleic acid in which each can be found: a. Cytosine________Py Both________________b. Guanine________Pu Both_____________c. Thymine________Py DNA only_____________d. Uracil____________Py RNA only______________e. Adenine__________Pu Both____________3. ATP is a: a. Ribonucleotideb. Deoxyribonucleotidec. Ribonucelosided. Deoxyribonucleoside4. Which of these nucleotides is formed through the addition of a pre-formed base during de novo synthesis. {Pyrimidine/Purine} 5. During de novo synthesis, the initial pyrimidine ring is comprised of {carbamoyl phosphate and aspartate, carbamoyl phosphate and glutamine, bicarbonate and glycine}6. Carbamoyl Phosphate is comprised of what 3 metabolites: a. ______Bicarbonate______b. ______ATP _____________c. ______ Amino group ___7. Place these intermediates in order of their synthesis: Uridylate, Thymidylate, Orotodylatea. _________ Orotodylate _____b. ________ Uridylate ___c. _________TTP____________8. This common nucleoside monophosphate is an intermediate in de novo purine synthesis for the synthesis of both Adenine and Guanine: ____IMP Inosine monophosphate__________9. It is a common strategy to phosphorylate a keto group to form an activated intermediate for addition of an amino group. In the synthesis of AMP, what is the source of the phosphate? ____GTP___________ And for GMP?__ ATP ______Self-Assessment Lecture 33: Nucleotide Function and Synthesis10. What is the activated ribose platform upon which salvaged bases are added inthe salvage pathway? __________ PRPP ___________________________________11. Please name the enzymes that catalyze the transfer of salvaged purine guanine and hypoxanthine bases to the activated ribose in Q11_____Phosphoribosyltransferases (HGPRT for instance) ______12. Please name the two products of Thymidylate Synthasea. __________ Thymidylate ____________________________________b. __________ Dihydrofolate________________________13. Please name a drug which inhibits thymidylate synthesis a. ____ Fluorodeoxyuridylate, Methotrexate, Aminopterin_____Other things to study from this lecture Lesch Nyhan Syndrome, Ribonucleotide reductase –

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