Wright BIO 2110 - BIO2110_exam3_fall2014 (14 pages)

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BIO2110_exam3_fall2014



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BIO2110_exam3_fall2014

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Pages:
14
School:
Wright State University
Course:
Bio 2110 - Principles of Molecular and Classical Genetics
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Name BIO 2110 Exam 3 5 November 2014 10 questions 10 points question see last page for potentially useful formulae show your work on all problems Name Name 1 Shown below is an alignment of five different random sequences taken from a population From this alignment estimate the effective population size Ne based on both the nucleotide diversity and the number of segregating sites k 10 8 mutations generation nucleotide Positions with nucleotide variation shaded 1 2 3 4 5 GATCAGTCAT GATCAGTCAT GATCAGTCAT GATCAGTCAT GATCAGTCAT ACGGATCCTA ACCGATCCTA ACGGATCCTA ACGGATCCTA ACGGATCCTA GACTACGACT GACTACGACT GACTACGACT GACTACGACT GTCTACGACT AGCCTAGCAT AGCCTAGCAT AACCTAGCAT AACCTAGCAT AGCCTAGCAT CCGAAATCAA CCGAAATCAA CCGAAATCAA CCGAAATCAA CCGAAATCAA Name 2 The frequency at which humming fish hum is determined by allelic variation at a single gene see below This variation has selective consequences lowered pitched hums can be used to communicate over greater distances than higher pitched hums Given this selective regime and an initial frequency of the A allele of p 0 2 what allelic and genotypic frequencies would you expect after two generations of selection genotype AA Aa aa phenotype 60 Hz 60 Hz 470 Hz relative fitness WAA 1 0 WAa 1 0 Waa 0 3 Name 3 In two populations of giraffes average neck lengths are six feet long In crosses between these giraffe populations F1 progeny have six foot long necks Neck lengths in F2 progeny vary from two feet long to ten feet long Out of 1 792 F2 giraffes seven have necks that are two feet long i Why does phenotype variation appear in the F2 generation when it is absent in the F1 and P0 generations ii How many genes are involved in neck length variation in these giraffes iii What other neck lengths would be observed in the F2 generation iv Out of 1 792 giraffes how many would be expected in each phenotypic class Name 4 In populations of medieval flying rabbits one locus A on chromosome 3 has been found responsible for the carnivorous diet phenotype Geneticists want to determine if an adjacent locus on chromosome 3 is in linkage equilibrium with locus A It appears that the carnivorous diet phenotype is greatly associated with the long fang phenotype locus B recombinants are rare i e long fanged vegans not so prominent in the population Determine the relationship between these loci using the sample population given below Are these two loci in linkage equilibrium If not then what is the disequilibrium value for this population variant positions high lighted A Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind Ind A B C D E F G H I J K L M N O P Q R S T GACTA GAGTA GAGTA GAGTA GAGTA GACTA GACTA GACTA GAGTA GACTA GACTA GAGTA GACTA GACTA GAGTA GAGTA GACTA GAGTA GACTA GAGTA B CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA CCCTA GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC GGTAC TAACT AAACT AAACT AAACT AAACT AAACT AAACT AAACT TAACT AAACT AAACT TAACT AAACT TAACT TAACT TAACT AAACT TAACT AAACT TAACT TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG TTTGG locus A carnivorous diet A1 C A2 G locus B long fang B1 A B2 T Name 5 In a population of barbary cats vocalizations are determined by allelic variation at the voc gene vocM homozygotes meow vocR homozygotes roar and vocM vocR heterozygotes bark A census of vocalization sounds in 1 000 barbary cats is shown below Based on these data what is the inbreeding coefficient FIS for this barbary cat population vocalization number meow 553 bark 294 roar 153 Name 6 The average per nucleotide divergence between two species of grackles is 0 0156 The mutation rate in these species is 3 x 10 8 mutations per nucleotide per generation Assuming neutrality how many generations has it been since these grackle species diverged Name 7 Wing length in pterodactyls is a quantitative character From a QTL study QTL and no QTL probabilities for three markers are shown below Based on these probabilities which of these markers would be linked to a QTL involved in the regulation of wing length Use a Lod score of 3 0 as your cut off for significance Show your work marker A1 3 C2 6 E6 9 probabilities QTL no QTL 0 9900 0 0100 0 9993 0 0007 0 8692 0 1308 Name 8 In Dendrobates leucomelas variation in toxin secretion results from allelic variation in a single gene The presence of toxins is dominant In population A 84 of frogs secrete toxins pA 0 0 6 In population B 36 of frogs secrete toxins pB 0 0 2 Frogs migrate from population A to population B mA B 0 1 but not from population B to population A mB A 0 0 How would allelic and genotypic frequencies change in population B over two generations of migration Name 9 Hump number in Dactrianedary camels varies from 1 to 3 This variation results from allelic variation in a single gene Dominance relationships among the three alleles of this gene are shown below In one population there are 510 three humped camels 130 two humped camels and 360 one humped camels Based on the frequencies of these phenotypes what are the frequencies of each allele in this population genotype HH Hh H number of humps three hh h two one Name 10 In a population of 1 531 zebras a recessive mutation arises that results in the absence of stripes What is the initial frequency of this mutation Assuming selective neutrality what are the initial probabilities of fixation and extinction for this allele Name Name p2 q2 r2 2pq 2pr 2qr 1 pn 1 WAA p2 WAa pq FIS 1 fAa 2pq 1 2N 2N 1 2N W PA1 G1 G2 p q r 1 pB n 1 pB n 1 mA B pA n mA B W WAA p2 WAa 2pq Waa q2 t d 2 T a 1 1 3 1 n 1 Dn Gn En W k a n number of classes 1 2 4Ne odds QTL prob QTL prob no QTL n log freq of extreme classes log Lod log10 odds 1 1 1 1 6 5 1 4 15 k 1 3 10 1 2 6 20 1 3 10 1 4 15 1 5 1 6 1 1 w


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