# Wright BIO 2110 - BIO2110_exam3_fall2015 (14 pages)

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## BIO2110_exam3_fall2015

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- School:
- Wright State University
- Course:
- Bio 2110 - Principles of Molecular and Classical Genetics

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Name BIO 2110 Genetics Exam 3 11 December 2015 10 questions 10 points per question see last page for potentially useless formulae calculators permitted SHOW YOUR WORK 1 Below is shown a comparison of four sequences from a single population Segregating sites indicated with arrowheads Based on this comparison estimate the effective size Ne of this population Show your work Assume a mutation rate of 10 8 mutations per nucleotide per generation 1 2 3 4 AGATC AGAAC AGAAC AGAAC AGCCT AGCCT AGCCT AGCCT AAGAT AATAT AATAT AATAT CATAC CATAC CATAC CATCC GATAC GATAC GATAC GATAC GGACT GGACT GGACT GGACT TTTCT TTTCT TTTCT TTTCT TCCTG TTCTC TCCTC TTCTC ACGAT ACGAT ACGAT ACGAT CAGTT CAGTT CAGTT CAGTT 2 In a population of saber tooth tigers allelic variation in a single gene determines fang length Dominance relationships and phenotypic distribution of fang lengths are shown below Based on these data determine the frequencies of all alleles and genotypes in this population Assume the population is in equilibrium genotype GG Gg G phenotypic fang length frequency 9 cm 0 19 gg g 13 cm 0 32 17 cm 0 49 3 In geoducks syphon length is determined by allelic variation in a single gene In one population of geoducks there are two alleles B and b The initial frequency of the b allele in this population q0 is 0 8 The relative fitnesses of the different genotypes are shown below i determine the mean fitness of this population ii determine the frequencies of both alleles after one generation of selection WBB 1 0 WBb 0 9 Wbb 0 3 4 Below are shown the results of a QTL on study club size in mantis shrimp Based on the results shown what is the minimum number of genes on chromosome 7 impact mantis shrimp club size What criterion was used to make this determination 7 6 5 4 Lod 3 2 1 0 4 8 position Mb on chromosome 7 12 16 5 Below are shown ten sequences from a population in which variation is observed in the A and B loci indicated by arrowheads These sequences are grouped by gamete type i e G1 A1B1 G2 A1B2 G1 A2B1 G1 A2B2 Based on these data determine linkage disequilibrium values for the A and B loci in this population A1 A A2 G B1 T B2 C A locus B locus GATCA GTTCA TTCAA AATAT GTATA CATAC CCATC GTACT GACTA GTACT GATCA GTTCA TTCAA AATAT GTATA CATAC CCATC GTACT GACTA GTACT GATCA GATCA GATCA GATCA GTTCA GTTCA GTTCA GTTCA TTCAA TTCAA TTCAA TTCAA AATAT AATAT AATAT AATAT GTATA GTATA GTATA GTATA CACAC CACAC CACAC CACAC CCATC CCATC CCATC CCATC GTACT GTACT GTACT GTACT GACTA GACTA GACTA GACTA GTACT GTACT GTACT GTACT GATCA GTTCG TTCAA AATAT GTATA CATAC CCATC GTACT GACTA GTACT GATCA GTTCG TTCAA AATAT GTATA CACAC CCATC GTACT GACTA GTACT GATCA GTTCG TTCAA AATAT GTATA CACAC CCATC GTACT GACTA GTACT GATCA GTTCG TTCAA AATAT GTATA CACAC CCATC GTACT GACTA GTACT 6 Two populations of apatosaurs differ in average mass In one population adults are 34 tons In the other population adults are 36 tons Seven phenotypic classes ranging from 32 to 38 ton are obtained in F2 progeny derived from crosses between these populations i how many genes are involved in the regulation of body mass in apatosaurs ii if 3 F2 apatosaurs are obtained that weigh 32 tons then how many apatosaurs would you expect in the other size classes iii what genetic structure in the P0 populations would allow for the results shown below i e what were the genotypes of the P0s P0 34 tons x 36 tons F1 35 tons x 35 tons F2 32 tons 33 tons 34 tons 35 tons 36 tons 37 tons 38 tons 7 Allelic variation in a single gene regulates alcohol tolerance in the hypotrichous ciliate Euplotes crassus Dominance relationships for this gene are shown below Also shown below are the numbers of individuals in a population that exhibit different tolerance levels Based on these data how does the structure of this population depart from expectations for a population in Hardy Weinberg equilibrium Provide a quantitative measure to describe this departure from equilibrium genotype AA Aa aa alcohol tolerance LD50 17 13 9 number in phenotype 480 240 280 8 In a population of 3600 diploid organisms what is the initial frequency of each new mutation that occurs What is the neutral probability of fixation for these new mutations What is the neutral probability of extinction for these new mutations 9 Yellow spotted lizards can either have seven spots or nine spotted Variation in spot number is regulated by allelic variation in a single gene Dominant homozygotes and heterozygotes have seven spots Recessive homozygotes have nine spots Two populations of lizards vary in the frequencies of seven spotted and nine spotted individuals Determined genotypic frequencies for these populations after one generation of migration Initial population structure and migration rates are shown below Assume migration is the only departure from Hardy Weinberg equilibrium Phenotype seven spotted nine spotted Population 1 510 490 migration coefficients m1 2 0 0 m2 1 0 1 Population 2 840 160 10 The divergence d between two populations of red winged locust is 0 00047 Assuming a mutation rate of 1 x 10 8 what is the divergence time in generations between these populations WAAp2 WAa2pq Waaq2 W e mc2 F 1 p1 n 1 1 m2 1 p1 n m2 1 p2 n p2 q2 r2 2pq 2pr 2pr 1 p q r 1 pn 1 WAAp2 WAapq W T PA1 GA1B1 GA1B2 EA1B1 PA1 PB1 e h p q 1 p2 2pq q2 1 d 2 t Lod Log10 odds d 2kt k 1 1 1 6 1 5 n 1 4 15 a 1 1 3 1 n 1 W k a DA1B1 EA1B1 GA1B1 4Ne odds QTL 1 3 10 1 2 6 20 1 3 10 1 4 15 1 5 1 6 1 1 n c 1 2

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