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Wright BIO 2110 - Rec9_sequence conservation

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BIO$2110$–$Recitation$9$ 17$November$2017$$Name$______________________$$Names$of$group$members$______________________$$$___________________________$$_______________________$$1.$$Below$is$shown$a$partial$sequence$of$a $ highly$conserved$protein-coding$gene.$$Also$shown$are$the$amino$acids$that$are$coded$for$by$this$DNA$sequence.$$Mutations$that$change$any$any$of$the$amino$acids$in$this$sequence$result$in$complete$loss$of$protein$function$and$are$recessive$lethal$mutations.$$$Of$the$three$nucleotides$indicated$by$arrowheads,$(the$G$in$the$Ser$codon,$the$C$in$the$Arg$codon,$the$A$in$the$Leu$codon);$i.$ which$would$be$most$highly$conserved$(least$variation)$ii.$ which$would$be$least$highly$conserved$(most$variation)$iii.$explain$you$answers$for$i$&$ii.$$ ▼ ▼ ▼ ATG TGG AGC CGA CAG CTA Met Trp Ser Arg Gln Leu $$$ $$2.$ In$the$diagram$below,$the$positions$of$ortholog$pairs$are$plotted$on$the$C.#elegans$(Y-axis)$and$C.#briggsae$(X-axis)$X$chromosomes.$i.$ knowing$the$sequences$of$both$genomes,$how$would$you$identifiy$pairs$of$orthologs?$ii.$ what$assumption$is$made$in$sequence-based$identification$of$orthologs?$iii.$ what$would$this$plot$look$like$if$the$X$chromosomes$of$C.#elegans$and$C.#briggsae$were$identical?$iv.$


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