Wright BIO 2110 - Rec3_Transcription (2 pages)

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Rec3_Transcription



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Rec3_Transcription

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2
School:
Wright State University
Course:
Bio 2110 - Principles of Molecular and Classical Genetics

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BIO 2110 Genetics Recitation 2 Transcription Name Group Members The C terminal domain CTD of the large subunit of eukaryotic RNA polymerase II pol II contains several repeats of the amino acid sequence YSPTSPS Phosphorylation of serine 5 S5 is involved in the transition from transcription initiation to elongation and in the capping of nascent pol II transcripts The phosphorylation of serine 2 S2 is involved in splicing and polyadenylation Y tyrosine S serine P proline T threonine 1 Which if any CTD serines are phosphylated on pol II that is not bound to DNA on pol II during transcription initiation on pol II during transcription elongation on pol II during transcription termination 2 What enzyme phosphorylates pol II during transcription initiation Why doesn t this enzyme phosphorylate pol II during elongation or termination 3 S5 phosphorylation is involved with two activities during transcription What are they How does S5 phosphorylation facilitate these activities 4 S2 phosphorylation is involved with two activities during transcription What are they How does S2 phosphorylation facilitate these activities How is it possible for S2 phosphorylation to facilitate both of these activities i e why aren t these activities mutually exclusive 5 Polyadenylation of pol II transcripts is functionally associated with pol II transcription termination Explain this functional relationship 6 What structure protects the 5 ends of eukaryotic mRNAs from degradation by 5 exonucleases What features of this structure are unique or unusual Feel free to draw this structure as part of your explanation 7 After a transcript is cleaved just after the polyadenylation signal the part of the RNA still associated with pol II does not acquire a 5 cap Why not What happens to this RNA molecule



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