BIO$2110$–$Genetics$ $ Name$____________________________$Recitation$4$–$Splicing$and$mRNA$export$$Group$Members$______________________$$$$$$_____________________________$$$$_____________________________$$1. Below$are$shown;$$i) An$RNA$pol$II$transcript$that$includes$two$exons$and$one$intron.$$Selected$sequences$in$this$transcript$are$shown.$ii) Two$snRNPs.$$Shaded$‘shapes’$in$these$diagrams$represent$the$protein$components$of$the$snRNPs.$$Lines$represent$the$RNA$components$of$the$snRNPs.$$Selected$sequences$in$the$snRNAs$are$shown.$$Indicate$where$each$of$the$snRNPs$would$bind$to$the$pol$II$transcript.$$Explain$why$these$snRNPs$would$bind$at$these$specific$locations$on$the$ t ranscript.$$Draw$the$on$the$transcript$the$molecular$interactions$that$would$result$these$snRNPs$binding$at$these$sit es.$$$$$$$$$$$$$$$$$snRNP-A $$snRNP-B $$ $BIO$2110$–$Genetics$ $ Name$____________________________$Recitation$4$–$Splicing$and$mRNA$export$$Group$Members$______________________$$$$$$_____________________________$$$$_____________________________$$2.$ How$does$the$binding$of$snRNPs$to$an$int ron$facilitate$splicing?$$What$is$the$ role$of$the$branch$point$adenosine$in$splicing?$$$$$$$$$$$$$$$$$$$$$3.$
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