Wright BIO 2110 - BIO2110_exam2_fall2014 (14 pages)

Previewing pages 1, 2, 3, 4, 5 of 14 page document View the full content.
View Full Document

BIO2110_exam2_fall2014



Previewing pages 1, 2, 3, 4, 5 of actual document.

View the full content.
View Full Document
View Full Document

BIO2110_exam2_fall2014

51 views


Pages:
14
School:
Wright State University
Course:
Bio 2110 - Principles of Molecular and Classical Genetics
Unformatted text preview:

Name BIO 2110 Exam 2 31 October 2014 10 questions 10 points per question see last page for potentially useless formulae bonus question on back of cover page Name Bonus question 2 pts Below is an epistatic pathway for dorsoventral axis specification in Drosophila embryos What is the medical relevance of this pathway sp tzle dorsal cactus pelle toll snake easter one sentence answers only Name 1 What type of mutation would more likely have a deleterious effect on gene function a point mutation in codon 3 a two nucleotide deletion in codon 3 or a three nucleotide deletion in codon 3 Explain your answer Name 2 Below is shown a Punnett Square for a monohybrid cross On this diagram indicate where i sperm genotypes are represented ii oocyte genotypes are represented iii what frequencies would be expected for each of these genotypes iv where genotypes of zygotes would be represented If AA homozygotes had large ear and aa homozygotes had small ears what additional information would you need to predict the frequencies of large and small eared individuals in the next generation A A a a Name 3 The halosis hal bellum bel jajunium jaj and nox nx genes all are on chromosome 3 in Beatus pallentes Based on the data shown below what is the order of these genes on this chromosome cross 1 hal bel nox HAL BEL NOX x hal hal hal bel nox HAL BEL NOX 360 360 hal bel NOX HAL BEL nox 90 90 hal BEL nox HAL bel NOX 40 40 HAL bel nox hal BEL NOX 10 10 bel nox bel nox cross 2 hal jaj nox HAL JAJ NOX x hal hal hal jaj nox HAL JAJ NOX 486 486 hal jaj NOX HAL JAJ nox 66 66 hal JAJ nox HAL jaj NOX 6 6 HAL jaj nox hal JAJ NOX 42 42 jaj nox jaj nox Name 4 In the following cross indicate the frequencies you would expect the selected F2 phenotypes Assume P0s are homozygous for all genes involved What other assumption is need to calculate these expected frequencies P0s hairy blue nose two fingers red eyes scabarous x hairless noseless one finger green eyes smooth F1s hairy red nose one finger red eyes scabarous x hairy red nose one finger red eyes scabarous F2 phenotype expected frequency hairy red nose one finger red eyes scabarous hairless blue nose two fingers green eyes smooth hairy noseless one finger green eyes scabarous Name 5 Wild type hippogriffs have a single pair of wings Recessive mutations in some genes result in wingless hippogriffs and recessive mutations in other genes result in hippogriffs with two pairs of wings the biwinged phenotype Based on the data presented below construct an epistatic pathway for the regulation of wing development in hippogrffs genotype nowings wingsgone sanswing wingsome winger phenotype wingless wingless wingless biwinged biwinged nowings wingsome nowings winger wingsgone wingsome wingsgone winger sanswings wingsome sanswings winger wingless biwinged biwinged biwinged wingless biwinged Name 6 Platypus eyes can be red or blue They also can have round or slit pupils Variation in each of these phenotypes is regulated by allelic variation at a single gene These genes are linked Based on the data presented below determine the recombination distance between these genes P0s are homozygous P0 red eye round pupil x blue eye slit pupil F1 blue eye slit pupil x blue eye slit pupil F2 blue eye slit pupil blue eye round pupil red eye slit pupil red eye round pupil 62 11 11 16 Name 7 Genetic variation in the mtlc and lmb genes of blue headed skinks affects head color and the presence or absence of legs Based on the data presented below are these genes linked Justify your answer statistically P0s are homozygous gene mtlc allele mtlc mtlc homozygous phenotype head metallic blue head slate blue lmb lmb lmb legs present legs absent generation head legs P0 metallic present head legs slate Absent metallic Present x F1 metallic present x F2 metallic metallic slate slate present absent present absent 923 277 277 123 Name 30 cM la cu mo LA CU MO x la cu mo LA CU MO 270 270 la cu MO LA CU mo 80 80 la CU mo LA cu MO 20 20 LA cu mo la CU MO 130 130 la cu mo la cu mo oe m cu la rr y rly 8 The larry la curly cu and moe mo genes are on the same chromosome see below Based on the segregation data shown how much if any crossover interference is present in this region of the genome 20 cM Name 9 When during meiosis i ii iii iv do homologous chromosomes pair does recombination occur between homologous chromosomes do homologous chromsomes disjoin do sister chromatids separate Name 10 Observations from a dihybrid cross of two unlinked autosomal genes are shown below P0s are homozygous i what phenotypes are controlled by each of the two genes involved ii which phenotypes are dominant and recessive iii what frequencies would you expect for each of the F2 phenotypes iv why is a novel phenotype that is not seen in P0s observed in the F2s P0 red eyes x eyeless F1 red eyes x F2 red eyes yellow eyes eyeless red eyes Name Name probability df 0 90 0 50 0 20 0 05 0 01 0 001 1 0 02 0 46 1 64 3 84 6 64 10 83 2 0 21 1 39 3 22 5 99 9 21 13 82 3 0 58 2 37 4 64 7 82 11 35 16 27 4 1 06 3 36 5 99 9 49 13 28 18 47 5 1 61 4 35 7 29 11 07 15 09 20 52 2 values 2 obs exp 2 exp Lod Log10 odds p2 q2 r2 2pq 2pr 2qr 1 p q 1 recombinant gamete frequency p T prob12 prob1 x prob2 pn 1 pn2WAA pnqnWAa W 1 nd 2 div 2 p N 2 x p q r 1 r ln N t2 N t1 t2 t1 1 TT 3 NPD 2 p N p2 classes 2n 1 W p2WAA 2pqWAa q2Waa df n 1 parental gamete frequency 1 p Nt N0 x e rt p2 2pq q2 1 b b 4ac 2a C DCOobs DCOexp par 1 p 1 cM equals a recombination frequency of 0 01 a 1 1 n 1 qn 1 qn2Waa pnq nWAa W 4Ne classes log10 freqext log10 1 W k a I 1 C odds probx prob0 5 rec p pn p0e n 1 1 3 1 2 3 Eco RI GAATTC 1 1 4 6 4 1 5 10 10 5 1 1 6 15 20 15 6 1 1 7 21 35 35 21 7 1 heterozygote frequency 2pq n 1 1 1 2Ne 1 2Ne 1 2Ne SCO DCO k fraction of segregating sites average frequency of nucleotide differences in pairwise sequence comparisons


View Full Document

Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...
Login

Join to view BIO2110_exam2_fall2014 and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view BIO2110_exam2_fall2014 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?