BCHM 3050 1st Edition Lecture 25 Outline of Last Lecture I Formation of the Prokaryotic Initiation Complex continued II Peptide Elongation III Peptide Bond Formation IV Termination of Translation V Some Transitional Differences in Eukaryotes Outline of Current Lecture I Transcriptional Regulation II Epigenetic Regulation III Regulation of Gene Expression Current Lecture I Transcriptional Regulation a Histones Heterochromatin negative regulation 1 Euchromatin positive regulation b Histones are positively charged due to lysine and arginine c Is an acetyl group adds to a lysine acetylation to form euchromatin positive regulation d Deacetylation heterochromatin negative regulation e Methylation heterochromatin f Demethylation euchromation g Lysine and arginine can go through methylation These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute II Epigenetic Regulation a Methylation of DNA C CH3 b Identical twins start out with the same exact DNA but likely grow up exposed to slightly different elements and environments causing genetic changes and epigenetic effects c Methylation of DNA is a down regulator negative regulator of transcription III Regulation of Gene Expression a Promoters bind RNA polymerase and sometimes activators b Activation proteins Enhancers c Activators RNA polymerase proteins promotes d Modulators middle man that are sometimes needed but not always protein example of positive regulator i Connect RNA polymerase with activator e Enhancers promoters silencers are DNA f Activators RNA polymerase repressors are proteins that bind to DNA
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