BIOL 640 1stdition Lecture 20Outline of Last Lecture I. Ag driven blast transformationOutline of Current Lecture II.Docking mechanismIII. BiozziIV. MitchensonCurrent LectureImmunology Lecture 21: T cell and B cell docking mechanism:T cell docks on MHC II and CD28.B7.CD 28 interaction ligand receptor type which results in blast transformation of T helper cells.CD40.CD40 ligand receptor type results in blast transformation of B cell. B7.CTAL4 interaction turns off T helper cell blast transformation. Therefore, does not help B cell.T reg completely shuts system.Blast transformation of T helper cells results in amplication by replication and differentiation.Biozzi:Some mice made many Ab and some less. Therefore, some are low responders as moderate rate of Ab made and some are high responders as high amounts of Ab produced. Low Ab producers have high activity of proteases in lysosomes and hence low Ab producers have no peptides for presentation. High Ab producers have low proteases activity in lysosomes and more peptides for presentation.These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.Mitchenson:For anamestic response 2 cells are needed:1. Memory T cells2. Memory B cells with B cell receptor Ig M and Ig D with idiotype that is DNP specific.Blast transformation when memory cells recognize carrier specific on B cell and T cell recognize ova receptor on macrophages. Prime reaction occurs between carrier specific memory T cell and epitope specific memory B cell.Adoptive transfer:Homo polymer: T independentMonomer: T dependentPolymeric cross linking B cell receptors thus trigger blast transformation independent of T helper cells.Homo polymer: Monomers are identical. One idiotype and one binding site. Also, more than one dockingby MHC II and TCR to cross link
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