BIOL 640 1st Edition Lecture 19Outline of Last Lecture I. Immunodeficiency HIV Outline of Current Lecture II.Ag driven blast transformationIII. Digest and dissect mechanism in B cellIV. Criteria to make AbCurrent LectureImmunology Lecture 20- Ag driven blast transformation:Antigen presenting cell (macrophages) with MHC II is recognized by T helper cell receptor and T helper cell becomes T helper cell lymphocyte. Dentritic cells, B cells and peptides are professional APC.Not self cells as T helper cell receptors. As T cells mature in thymus, T cells recognize self peptides on MHC II will die as a result of tolerance to self.All B cells are resting mature cells with receptors for making Ab for Ag.There are 2 different Ag presentation: Macrophages MHC II has APC and B cells APC MHC II to ingest, digest, and display same Ag peptide on MHC II to alert immune system.Digest and dissect mechanism in B cells:B cells ingest, digest, and individual peptides are displayed.MHC II has no conformational epitope as it is destroyed. It has no DNP conjugate as destroyed as well. It can only see peptides derived from molecules that are sequrntial epitope as well as peptide from deep inside (not even an epitope from deep inside).These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.Criteria to make Ab:Ag presenting cell is presenting an Ag derived peptide on MHC II and recognized by T helper cell via its T cell receptors.At the same time, B cell recognizes epitope of Ag immunoglobulin receptor and displays Ag derived peptide on MHC II which T helper cell has on its receptor, identical to B cell MHC II.Then T helper cell enables B cell blast transformation to plasma cells where Ig specified for cell specified.B cell receptors are not manipulated but T cell receptors are already manipulated.T cell receptor Ag in peptide not recognized then T cell killed by
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