SC BIOL 620 - Nucleotide Biosynthesis (4 pages)

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Nucleotide Biosynthesis

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Nucleotide Biosynthesis


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Lecture Note
University Of South Carolina-Columbia
Biol 620 - Immunobiology

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BIOL 460 1st Edition Lecture 7 Outline of Last Lecture I Allotype Outline of Current Lecture II Rh factor III Ig A Ig E IV Degranulation Current Lecture Immunology Lecture 8 Nucleotide biosynthesis When Rh father and Rh mother conceive a child that is Rh ERYTHROBLASTOSIS FETALIS develops where the mother has made antibodies as a result of exposure to Rh during the first delivery The alpha Rh Ab have Ig G isotype and cross placenta These already present antibodies during subsequent delivery 2 nd child birth can attack and destroy RBC of fetus Ig A found in abundance in external secretions such asMucus 5 15 g day Saliva Tears Breast milk Sperm cells Animal sperm cells are more energy consuming and made only during mating season These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Ig A in breast milk is responsible for healthy infants in daycare centers Mothers who are exposed produce Ab specific for the microbes in the daycare center Breast milk fed child receives these Ab from the mother and are healthier than other children This is partly due to Ig A in serum persists as a monomer whereas the secreted Ig A is a dimeric with secretory component with a J chain in the center During early development Ab can not through intestinal cell walls and needs protection Ab made for environment made by the mother and passed onto the child through breast milk Ig A as a dimer In the epithelial cells there are poly receptors which bind to Ig A and promote phagocytosis and part of the receptor cleaved off Ig A on the surface binds to bacteria or virus attachment to viral or bacterial membranes are affected by Ig A Ig E found in low serum level also in hypersensitivity i e allergic reaction Role protection against intestinal parasites As there are many parasites in III world countries immune system is working and less sensitive to allergens exists as not a free form but on the surface

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